A
Akinori Sarai
Researcher at Kyushu Institute of Technology
Publications - 225
Citations - 10469
Akinori Sarai is an academic researcher from Kyushu Institute of Technology. The author has contributed to research in topics: DNA & Base pair. The author has an hindex of 49, co-authored 225 publications receiving 9663 citations. Previous affiliations of Akinori Sarai include National Institutes of Health & Japan Atomic Energy Research Institute.
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PrognoScan: a new database for meta-analysis of the prognostic value of genes
TL;DR: PrognoScan employs the minimum P-value approach for grouping patients for survival analysis that finds the optimal cutpoint in continuous gene expression measurement without prior biological knowledge or assumption and, as a result, enables systematic meta-analysis of multiple datasets.
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Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas.
Hirokazu Okayama,Takashi Kohno,Yuko Ishii,Yoko Shimada,Kouya Shiraishi,Reika Iwakawa,Koh Furuta,Koji Tsuta,Tatsuhiro Shibata,Seiichiro Yamamoto,Shun-ichi Watanabe,Hiromi Sakamoto,Kensuke Kumamoto,Seiichi Takenoshita,Noriko Gotoh,Hideaki Mizuno,Akinori Sarai,Shuichi Kawano,Rui Yamaguchi,Satoru Miyano,Jun Yokota +20 more
TL;DR: An extensive genome-wide expression profiling of 226 primary human stage I-II lung adenocarcinomas helps identify patients who may gain the most benefit from adjuvant chemotherapy after surgical resection and further stratify more or less aggressive subgroups of triple-negative lung ADC.
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Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices.
Kazuhiro Ogata,Souichi Morikawa,Haruki Nakamura,Ai Sekikawa,Taiko Inoue,Hiroko Kanai,Akinori Sarai,Shunsuke Ishii,Yoshifumi Nishimura +8 more
TL;DR: The solution structure of a specific DNA complex of the minimum DNA-binding domain (R2R3) is determined by heteronuclear multidimensional NMR by determining that both R2 and R3 contain three helices, and the third helix in each is found to be a recognition helix.
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ProTherm and ProNIT: thermodynamic databases for proteins and protein–nucleic acid interactions
M. D. Shaji Kumar,K. Abdulla Bava,M. Michael Gromiha,Ponraj Prabakaran,Koji Kitajima,Hatsuho Uedaira,Akinori Sarai +6 more
TL;DR: ProTherm and ProNIT are two thermodynamic databases that contain experimentally determined thermodynamic parameters of protein stability and protein–nucleic acid interactions, respectively.
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Unique Mode of GCC Box Recognition by the DNA-binding Domain of Ethylene-responsive Element-binding Factor (ERF Domain) in Plant
TL;DR: Systematic DNA mutation analyses demonstrate that the specific amino acid contacts are confined within the 6-base pair GCCGCC region of the GCC box, and the first G, the fourth G and the sixth C exhibit highest binding specificity common in all three ERF domain-containing fragments studied.