K
Kazuhiro Shimomura
Researcher at Northwestern University
Publications - 42
Citations - 6594
Kazuhiro Shimomura is an academic researcher from Northwestern University. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 25, co-authored 40 publications receiving 6053 citations. Previous affiliations of Kazuhiro Shimomura include Howard Hughes Medical Institute & University of Wisconsin-Madison.
Papers
More filters
Journal ArticleDOI
Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse.
Lawrence H. Pinto,Martha Hotz Vitaterna,Kazuhiro Shimomura,Sandra M. Siepka,Victoria Balannik,Erin L. McDearmon,Chiaki Omura,Stephen Lumayag,Brandon M. Invergo,Brett Glawe,Donald R. Cantrell,Samsoon Inayat,Samsoon Inayat,Marissa A. Olvera,Kirstan A. Vessey,Maureen A. McCall,Dennis M. Maddox,Catherine W. Morgans,Brandon Young,Mathew T. Pletcher,Robert F. Mullins,John B. Troy,Joseph S. Takahashi +22 more
TL;DR: In nob4 mice, fewer retinal ganglion cells (RGCs) responded to the onset of a bright full field stimulus, and visual acuity and contrast sensitivity, measured with optomotor responses, were reduced under both photopic and scotopic conditions.
Journal ArticleDOI
Period2 3′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation
Seung Hee Yoo,Shihoko Kojima,Kazuhiro Shimomura,Nobuya Koike,Nobuya Koike,Ethan D. Buhr,Ethan D. Buhr,Tadashi Furukawa,Caroline H. Ko,Gabrielle F. Gloston,Christopher Ayoub,Kazunari Nohara,Bryan A. Reyes,Yoshiki Tsuchiya,Ook Joon Yoo,Kazuhiro Yagita,Choogon Lee,Zheng Chen,Shin Yamazaki,Carla B. Green,Joseph S. Takahashi +20 more
TL;DR: These results identified an important posttranscriptional regulatory mechanism of PER2 expression required for normal circadian timekeeping and provide important mechanistic insights into the regulatory roles of Per2 3′-UTR, miR-24, and PER2 in Per2 expression and core clock function.
Journal ArticleDOI
Transmissible microbial and metabolomic remodeling by soluble dietary fiber improves metabolic homeostasis
Baokun He,Kazunari Nohara,Nadim J. Ajami,Ryan D. Michalek,Xiangjun Tian,Matthew C. Wong,Susan H. Losee-Olson,Joseph F. Petrosino,Seung Hee Yoo,Kazuhiro Shimomura,Zheng Chen +10 more
TL;DR: Beneficial roles of RM-dependent microbial remodeling in metabolic homeostasis are elucidate, prevalent health-promoting potentials of dietary fibers are showcased, and metabolomic profiling illustrated broad changes.
Journal ArticleDOI
Interpretation of the mouse electroretinogram.
TL;DR: The mouse electroretinogram (ERG) consists of a complex set of signals or “waves” generated by multiple types of retinal cell, and the origins of these waves are reviewed briefly for the C57BL/6J mouse.
Journal ArticleDOI
Genetic analysis of the stress-responsive adrenocortical axis
Leah C. Solberg,Leah C. Solberg,Amber E. Baum,Nasim Ahmadiyeh,Kazuhiro Shimomura,Renhua Li,Fred W. Turek,Joseph S. Takahashi,Gary A. Churchill,Eva E. Redei +9 more
TL;DR: A quantitative trait locus (QTL) analysis in the segregating F2 generation of a Wistar Kyoto x Fischer 344 (F344) cross, two inbred rat strains, confirms that three separate traits regulated by the HPA axis are controlled by multiple, but mainly nonoverlapping, QTLs.