Ook Joon Yoo

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is demonstrated that peripheral tissues express self-sustained, rather than damped, circadian oscillations and the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level is suggested.

TL;DR: A model ofTLR4-MD-2 dimerization induced by LPS is proposed and a series of hybrids of human TLR4 and hagfish VLR are produced and their structures with and without bound MD-2 and Eritoran are determined.

TL;DR: A method for systematic integration of multiple microarray datasets and an alternative modeling procedure based on a Bayesian approach, which would offer flexibility and robustness compared to the classical procedure are established.

TL;DR: The mouse mPer2 promoter is analyzed and a circadian enhancer (E2) with a noncanonical 5'-CACGTT-3' E-box located 20 bp upstream of the m per2 transcription start site is identified, sufficient to drive self-sustained circadian rhythms of luciferase activity in central and peripheral tissues from mPer 2-E2::Luciferase transgenic mice with tissue-specific phase and period characteristics.