K
Kazuhito Hatanaka
Researcher at University of Tokyo
Publications - 14
Citations - 404
Kazuhito Hatanaka is an academic researcher from University of Tokyo. The author has contributed to research in topics: Ischemic preconditioning & Cytochrome c. The author has an hindex of 9, co-authored 14 publications receiving 389 citations.
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Journal ArticleDOI
Ischemic preconditioning upregulates vascular endothelial growth factor mRNA expression and neovascularization via nuclear translocation of protein kinase C epsilon in the rat ischemic myocardium.
Hiroyuki Kawata,Kenichi Yoshida,Atsuhiko Kawamoto,Hideyuki Kurioka,Eiji Takase,Yasunobu Sasaki,Kazuhito Hatanaka,Masahiko Kobayashi,Takashi Ueyama,Toshio Hashimoto,Kazuhiro Dohi +10 more
TL;DR: Results show that IP may enhance VEGF gene expression and angiogenesis through nuclear translocation of PKC&egr; in the infarcted myocardium.
Journal ArticleDOI
Role of Phasic Dynamism of p38 Mitogen-Activated Protein Kinase Activation in Ischemic Preconditioning of the Canine Heart
Shoji Sanada,Masafumi Kitakaze,Philip J. Papst,Kazuhito Hatanaka,Hiroshi Asanuma,Toshihiko Aki,Yoshiro Shinozaki,Hisakazu Ogita,Koichi Node,Seiji Takashima,Masanori Asakura,Junko Yamada,Tomi Fukushima,Akiko Ogai,Tsunehiko Kuzuya,Hidezo Mori,Naohiro Terada,Kenichi Yoshida,Masatsugu Hori +18 more
TL;DR: In this paper, the effects of selective p38 mitogen-activated protein kinase inhibition on the cardioprotective effect of ischemic preconditioning (IP) in open-chest dogs were examined.
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Down-regulation of connexin43 in early myocardial ischemia and protective effect by ischemic preconditioning in rat hearts in vivo.
TL;DR: It is believed that Cx 43 is dephosphorylated and degraded in early ischemia, whereas Cx43 transcription was suppressed at a later phase of ischemIA.
Journal ArticleDOI
Diagnosis of cyanide intoxication by measurement of cytochrome c oxidase activity.
Hiroshi Ikegaya,Hirotaro Iwase,Kazuhito Hatanaka,Koichi Sakurada,Ken-ichi Yoshida,Takehiko Takatori +5 more
TL;DR: The brain is considered to be the primary organ of cyanide intoxication in a rat, suggesting that the diagnosis may be possible by measuring not only the cyanide concentration but also the CCO activity.
Journal ArticleDOI
Development of rigor mortis is not affected by muscle volume
Masahiko Kobayashi,Hiroshi Ikegaya,Izumi Takase,Kazuhito Hatanaka,Koichi Sakurada,Hirotaro Iwase +5 more
TL;DR: Differences in pre-rigor load on the muscles influenced the onset and resolution of rigor mortis in a few pairs of samples, but did not influence the time taken for rigor Mortis to reach its full extent after death.