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Seiji Takashima
Researcher at Osaka University
Publications - 198
Citations - 10226
Seiji Takashima is an academic researcher from Osaka University. The author has contributed to research in topics: Adenosine & Heart failure. The author has an hindex of 52, co-authored 189 publications receiving 9342 citations. Previous affiliations of Seiji Takashima include Children's Medical Center of Dallas.
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Journal ArticleDOI
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy
Masanori Asakura,Masafumi Kitakaze,Seiji Takashima,Yulin Liao,Fuminobu Ishikura,Tsuyoshi Yoshinaka,Hiroshi Ohmoto,Koichi Node,Kohichiro Yoshino,Hiroshi Ishiguro,Hiroshi Asanuma,Shoji Sanada,Yasushi Matsumura,Hiroshi Takeda,Shintaro Beppu,Michihiko Tada,Masatsugu Hori,Shigeki Higashiyama +17 more
TL;DR: It is suggested that inhibition of HB-EGF shedding could be a potent therapeutic strategy for cardiac hypertrophy and that dominant-negative expression of ADAM12 abrogated this signaling.
Journal ArticleDOI
Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development
Wanyang Liu,Daisuke Morito,Seiji Takashima,Yohei Mineharu,Hatasu Kobayashi,Toshiaki Hitomi,Hirokuni Hashikata,Norio Matsuura,Satoru Yamazaki,Atsushi Toyoda,Ken-ichiro Kikuta,Yasushi Takagi,Kouji H. Harada,Asao Fujiyama,Asao Fujiyama,Roman Herzig,Boris Krischek,Li-Ping Zou,Jeongeun Kim,Masafumi Kitakaze,Susumu Miyamoto,Kazuhiro Nagata,Nobuo Hashimoto,Akio Koizumi +23 more
TL;DR: Evidence is provided suggesting, for the first time, the involvement of RNF213 in genetic susceptibility to moyamoya disease, and a founder haplotype transmitted in 42 families is revealed.
Journal ArticleDOI
Prolonged Endoplasmic Reticulum Stress in Hypertrophic and Failing Heart After Aortic Constriction Possible Contribution of Endoplasmic Reticulum Stress to Cardiac Myocyte Apoptosis
Ken-ichiro Okada,Tetsuo Minamino,Yoshitane Tsukamoto,Yulin Liao,Osamu Tsukamoto,Seiji Takashima,Akio Hirata,Masashi Fujita,Yoko Nagamachi,Takeshi Nakatani,Chikao Yutani,Kentaro Ozawa,Satoshi Ogawa,Hitonobu Tomoike,Masatsugu Hori,Masafumi Kitakaze +15 more
TL;DR: Findings suggest that pressure overload by TAC induces prolonged ER stress, which may contribute to cardiac myocyte apoptosis during progression from cardiac hypertrophy to failure.
Journal ArticleDOI
Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis
Seiji Takashima,Masafumi Kitakaze,Masanori Asakura,Hiroshi Asanuma,Shoji Sanada,Fumi Tashiro,Hitoshi Niwa,Jun-ichi Miyazaki,Seiichi Hirota,Yukihiko Kitamura,Takashi Kitsukawa,Hajime Fujisawa,Michael Klagsbrun,Masatsugu Hori +13 more
TL;DR: The results suggest that NRPs are early genes in embryonic vessel development and that both NP1 and NP2 are required.
Journal ArticleDOI
Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity
Michael L. Gagnon,Diane R. Bielenberg,Ze'ev Gechtman,Hua-Quan Miao,Seiji Takashima,Shay Soker,Michael Klagsbrun +6 more
TL;DR: The results demonstrate the existence of a naturally occurring, soluble NRP1 that is expressed differently from intact N RP1 and that appears to be a VEGF(165) antagonist.