Showing papers by "Kazunori Yamada published in 2012"
TL;DR: Although a recent unanimous consensus of all relevant researchers in Japan recently established the diagnostic criteria for IgG4-related disease, findings such as the authors' indicate that further discussion is needed.
Abstract: IgG4-related disease is a new disease classification established in Japan in the 21st century. Patients with IgG4-related disease display hyper-IgG4-gammaglobulinemia, massive infiltration of IgG4
134 citations
TL;DR: Based on this study (26%) and another report (33%), it is likely that nearly a quarter of orbital LPD are IgG4-ROI, which is an important differential diagnosis for lymphoproliferative disorders.
Abstract: The most frequent ocular adnexal tumors and simulating lesions are lymphoproliferative disorders (LPDs), including malignant lymphomas and orbital inflammation with lymphoid hyperplasia or infiltration IgG4-related orbital inflammation (IgG4-ROI) often involves lacrimal glands and other orbital tissues and is an important differential diagnosis The present study evaluated clinical aspects of IgG4-ROI in a case series of orbital LPD Sixty-two consecutive cases of orbital LPD, pathologically diagnosed from November, 2004, through March, 2011, were investigated Histological types were 22 cases with MALT lymphoma, 11 cases with diffuse large B-cell lymphoma (DLBCL), 3 cases with other malignant lymphomas, 16 cases with IgG4-ROI, and 10 cases with non-IgG4-ROI Ages of the IgG4-ROI group ( yrs) were significantly lower than the MALT lymphoma ( yrs) and DLBCL ( yrs) groups Orbital lesions other than lacrimal glands were present in six cases including extraocular muscle swelling, mass lesions surrounding the optic nerve, and supraorbital and infraorbital nerves enlargements Although none of the malignant lymphomas were related to IgG4, previous evidence suggested that malignant lymphomas can arise from IgG4-ROI Based on this study (26%) and another report (33%), it is likely that nearly a quarter of orbital LPD are IgG4-ROI
70 citations
TL;DR: This study shows that persistent renal insufficiency associated with macroscopic atrophy and microscopic fibrosis is not so rare in IgG4-related TIN, and the behavior of regulatory T cells during the clinical course is quite similar to that of IgG 4-positive plasma cells.
Abstract: Objectives
This study aimed to investigate the clinicopathological changes induced by corticosteroid therapy in immunoglobulin (Ig)G4-related tubulointerstitial nephritis (TIN).
46 citations