Clinical and histological changes associated with corticosteroid therapy in IgG4-related tubulointerstitial nephritis
Ichiro Mizushima,Kazunori Yamada,Hiroshi Fujii,Dai Inoue,Hisanori Umehara,Masakazu Yamagishi,Yutaka Yamaguchi,Michio Nagata,Masami Matsumura,Mitsuhiro Kawano +9 more
TLDR
This study shows that persistent renal insufficiency associated with macroscopic atrophy and microscopic fibrosis is not so rare in IgG4-related TIN, and the behavior of regulatory T cells during the clinical course is quite similar to that of IgG 4-positive plasma cells.Abstract:
Objectives
This study aimed to investigate the clinicopathological changes induced by corticosteroid therapy in immunoglobulin (Ig)G4-related tubulointerstitial nephritis (TIN).read more
Citations
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Journal ArticleDOI
IgG4-related kidney disease.
Takako Saeki,Mitsuhiro Kawano +1 more
TL;DR: Tubulointerstitial nephritis with increased IgG4-positive plasma cells and fibrosis is the most dominant feature of IgG 4-RKD and may cause acute or chronic renal dysfunction, although some glomerular lesions such as membranous nephropathy are sometimes evident.
Journal ArticleDOI
The clinical course of patients with IgG4-related kidney disease.
Takako Saeki,Mitsuhiro Kawano,Ichiro Mizushima,Motohisa Yamamoto,Yoko Wada,Hitoshi Nakashima,Noriyuki Homma,Yutaka Tsubata,Hiroki Takahashi,Tomoyuki Ito,Hajime Yamazaki,Takao Saito,Ichiei Narita +12 more
TL;DR: The response of IgG4-related kidney disease to corticosteroids is rapid, not total, and the recovery of renal function persists for a relatively long time under low-dose maintenance, suggesting a large-scale prospective study to formulate more useful treatment strategies is necessary.
Journal ArticleDOI
Characteristic tubulointerstitial nephritis in IgG4-related disease.
Yutaka Yamaguchi,Yukiko Kanetsuna,Kazuho Honda,Nobuaki Yamanaka,Mitsuhiro Kawano,Michio Nagata +5 more
TL;DR: The distinctive histologic features of IgG4-related tubuloInterstitial nephritis can facilitate the differential diagnosis of tubulointerstitial nephitis, even without autoimmune pancreatitis or an abnormal computed tomography suggesting a renal tumor.
Journal ArticleDOI
IgG4-related disease and the kidney
Frank B. Cortazar,John H. Stone +1 more
TL;DR: This Review, it is summarized current knowledge of IgG4-RD and its most frequent manifestations in the kidney—IgG 4-related tubulointerstitial nephritis (TIN) and membranous glomerulonephropathy (MGN).
Journal ArticleDOI
IgG4-related disease: a clinical perspective.
TL;DR: The first-line treatment of IgG4-RD is based on glucocorticoids, which are usually efficacious, but B cell depletion induced by rituximab has also been found to induce remission in steroid-resistant disease or has been used as steroid-sparing agent for relapsing disease.
References
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Journal ArticleDOI
High serum IgG4 concentrations in patients with sclerosing pancreatitis.
Hideaki Hamano,Shigeyuki Kawa,Akira Horiuchi,Hiroshi Unno,Naoyuki Furuya,Taiji Akamatsu,Mana Fukushima,Toshio Nikaido,Kohzo Nakayama,Nobuteru Usuda,Kendo Kiyosawa +10 more
TL;DR: Patients with sclerosing pancreatitis have high serum IgG4 concentrations, providing a useful means of distinguishing this disorder from other diseases of the pancreas or biliary tract.
Journal ArticleDOI
Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis.
Yoh Zen,Takahiko Fujii,Kenichi Harada,Mitsuhiro Kawano,Kazunori Yamada,Masayuki Takahira,Yasuni Nakanuma +6 more
TL;DR: AIPC is a unique inflammatory disorder characterized by an immune reaction predominantly mediated by Th2 cells and Tregs, which could be characterized by the over‐production of T helper (Th) 2 and regulatory cytokines.
Journal ArticleDOI
Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders
Yasufumi Masaki,Lingli Dong,Lingli Dong,Nozomu Kurose,Kazuko Kitagawa,Yuko Morikawa,Motohisa Yamamoto,Hiroki Takahashi,Yasuhisa Shinomura,Kohzoh Imai,Takako Saeki,Atsushi Azumi,Shinji Nakada,Eiji Sugiyama,Shoko Matsui,Tomoki Origuchi,Susumu Nishiyama,Isao Nishimori,Takayuki Nojima,Kazunori Yamada,Mitsuhiro Kawano,Yoh Zen,Masahiko Kaneko,Kana Miyazaki,Kazuo Tsubota,Katsumi Eguchi,Kouichi Tomoda,Toshioki Sawaki,Takafumi Kawanami,Masao Tanaka,Toshihiro Fukushima,Susumu Sugai,Hisanori Umehara +32 more
TL;DR: There are considerable clinical and pathological differences between IgG4+MOLPS and SS, and based on the clinical features and good response to glucocorticoids, a new clinical entity is proposed: IgG 4+MolPS.
Journal ArticleDOI
Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis
Hideaki Hamanou,Shigeyuki Kawa,Yasuhide Ochi,Hiroshi Unno,Nobuhiko Shiba,Masahisa Wajiki,Koh Nakazawa,Hisashi Shimojo,Kendo Kiyosawa +8 more
TL;DR: In this article, the ureteral and pancreatic lesions of 22 patients with sclerosing pancreatitis were histologically examined and found abundant infiltration of lgG4-bearing plasma cells in both tissues.
Journal ArticleDOI
Rituximab therapy leads to rapid decline of serum IgG4 levels and prompt clinical improvement in IgG4-related systemic disease.
TL;DR: Treatment with rituximab led to prompt clinical and serologic improvement in these patients with refractory IgG4-RSD, and is a viable treatment option for this condition, suggesting that ritUXimab achieves its effects in IgG 4- RSD by depleting the pool of B lymphocytes that replenish short-lived IgG3-secreting plasma cells.
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