K
Kazuo Nagasawa
Researcher at Tokyo University of Agriculture and Technology
Publications - 329
Citations - 6484
Kazuo Nagasawa is an academic researcher from Tokyo University of Agriculture and Technology. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 40, co-authored 311 publications receiving 5777 citations. Previous affiliations of Kazuo Nagasawa include Harvard University & University of Tokyo.
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Cyclooxygenase Inhibitors Derived from Thalidomide.
Mamiko Suizu,Yohei Muroya,Hiroki Kakuta,Hiroyuki Kagechika,Aya Tanatani,Kazuo Nagasawa,Yuichi Hashimoto +6 more
TL;DR: Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide as mentioned in this paper.
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Asymmetric α-Hydroxylation of a Lactone with Vinylogous Pyridone by Using a Guanidine—Urea Bifunctional Organocatalyst: Catalytic Enantioselective Synthesis of a Key Intermediate for (20S)-Camptothecin Analogues.
TL;DR: In this paper, the synthesis of (+)-C20-desethylbenzylcamptothecin (VIII) was demonstrated by the use of this method to synthesize (+-C20−desethyl benzylcimptotoxin.
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Synthesis of Pentacyclic Core Structure of Aspidosperma Alkaloids by Sequential Ring Construction Via Oxidative Phenolic Coupling
TL;DR: In this article , the common pentacyclic core structure of Aspidosperma alkaloids was assembled by means of a sequential ring construction strategy, and 6-exo-trig radical cyclization with V-601 as a radical initiator afforded the D ring with an all-carbon quaternary stereogenic center at C20.
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Stereoselective Construction of Tertiary Alcohol at C11 of Zetekitoxin AB
TL;DR: In this article , the authors describe the construction of the characteristic structure of ZTX at C11, focusing on the C−C bond and tertiary hydroxyl group, via two approaches, i.e., Mukaiyama-hydration reaction and 1,3-dipolar cycloaddition.
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Nucleophilic Substitution on 4-Hydroxymethylanilines under “Neutral” Conditions via Aza Quinone Methide Intermediate.
TL;DR: In this article, the substitution reaction of 4-hydroxymethylaniline derivatives with resonance-stabilized carbon nucleophiles and an acid-labile nucleophile, including β-ketoester, 1,3-diketone, α-nitroester, and silylenolether, proceeded efficiently upon heating at 80°C in a neutral solvent system.