K
Kazuo Nagasawa
Researcher at Tokyo University of Agriculture and Technology
Publications - 329
Citations - 6484
Kazuo Nagasawa is an academic researcher from Tokyo University of Agriculture and Technology. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 40, co-authored 311 publications receiving 5777 citations. Previous affiliations of Kazuo Nagasawa include Harvard University & University of Tokyo.
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Journal ArticleDOI
Stereoselective Synthesis of Novel Ptilomycalin A Analogs via Successive 1,3-Dipolar Cycloaddition Reactions and their Ca2+-ATPase Inhibitory Activity
Angelina Georgieva,Manabu Hirai,Yuichi Hashimoto,Tadashi Nakata,Yasushi Ohizumi,Kazuo Nagasawa +5 more
TL;DR: The pentacyclic guanidine compounds 4 and 5 were stereoselectively synthesized as novel ptilomycalin A and crambescidin analogs, and exhibited significant inhibitory activity against Ca 2 + -ATPase.
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Stereoselective Synthesis of Tricyclic Guanidine Systems: Confirmation of the Stereochemistry of Batzelladine F Left-Hand Tricyclic Guanidine Portion.
TL;DR: The stereoselective synthetic methods for anti-and syn-fused tricyclic guanidine compounds 4a and 4b were developed based on a successive 1,3-dipolar cycloaddition as mentioned in this paper.
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Synthesis of Deuterium-Labeled Vitamin D Metabolites as Internal Standards for LC-MS Analysis
A Nagata,Kazuto Iijima,Ryota Sakamoto,Yuka Mizumoto,Miho Iwaki,Masaki Takiwaki,Yoshikuni Kikutani,Seketsu Fukuzawa,Minami Odagi,Masayuki Tera,Kazuo Nagasawa +10 more
TL;DR: This is the first quantification of 1,25(OH)2D3-23,26-lactone (7) in human serum, and a versatile synthesis of deuterium-labeled D3 metabolites using A-ring synthons containing threedeuterium atoms is described.
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Novel Chiral Derivatizing Agents for 1H NMR Determination of Enantiomeric Purities of Carboxylic Acids
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Chemical Synthesis of Side-Chain-Hydroxylated Vitamin D3 Derivatives and Their Metabolism by CYP27B1.
Ryota Sakamoto,Akiko Nagata,Haruki Ohshita,Yuka Mizumoto,Miho Iwaki,Kaori Yasuda,Toshiyuki Sakaki,Kazuo Nagasawa +7 more
TL;DR: In this paper, the role of CYP27B1 in the C1 hydroxylation of a series of side-chain-hydroxylated D3 derivatives was explored.