K
Kazuo Nagasawa
Researcher at Tokyo University of Agriculture and Technology
Publications - 329
Citations - 6484
Kazuo Nagasawa is an academic researcher from Tokyo University of Agriculture and Technology. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 40, co-authored 311 publications receiving 5777 citations. Previous affiliations of Kazuo Nagasawa include Harvard University & University of Tokyo.
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Journal ArticleDOI
Sequential stereodivergent organocatalysis and programmed organocascades
Yoshihiro Sohtome,Kazuo Nagasawa +1 more
TL;DR: In this Perspective, the importance of in situ tunability in dynamic asymmetric organocatalysis for obtaining different functional outcomes with single-flask operation is emphasized.
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A caged ligand for a telomeric G-quadruplex.
TL;DR: The design, synthesis, and characteristics of the first example of a caged compound targeting telomeric G4 are described, which was confirmed to result in inhibition of telomerase activity in vitro and in growth inhibition of several cancer cell lines.
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Synthesis of Skeletal Analogues of Saxitoxin Derivatives and Evaluation of Their Inhibitory Activity on Sodium Ion Channels NaV1.4 and NaV1.5
Ryoko Shinohara,Takafumi Akimoto,Osamu Iwamoto,Takatsugu Hirokawa,Mari Yotsu-Yamashita,Kaoru Yamaoka,Kazuo Nagasawa +6 more
TL;DR: Skeletal analogues of saxitoxin (STX) that possess a fused-type tricyclic ring system, designated FD-STX, were synthesized as candidate sodium ion channel modulators, and their inhibitory activity on sodium ion channels was examined by means of cell-based assay.
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Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities.
Hisao Masai,Rino Fukatsu,Naoko Kakusho,Yutaka Kanoh,Kenji Moriyama,Yue Ma,Keisuke Iida,Kazuo Nagasawa +7 more
TL;DR: A model on how Rif1 may facilitate the formation of chromatin architecture through its G4 binding and oligomerization properties is presented.
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Synthetic study of marine macrolide swinholide A. stereocontrolled synthesis of the C11 - C23 segment
TL;DR: In this paper, the C11-C23 segment of swinholide A was synthesized stereoselectively starting from (S)-malic acid via double nitroaldol reaction under high pressure and differentiation of the left and right parts of the symmetric compound 10 as the key steps.