Kazushige Tsunoda

TL;DR: Intrinsic signal imaging from inferotemporal cortex revealed that visually presented objects activated patches in a distributed manner, suggesting that an object is represented by a combination of cortical columns, each of which represents a visual feature (feature column).

TL;DR: Children with childhood-onset STGD are associated with severe visual loss, early morphologic changes, and often generalized retinal dysfunction, despite often having less severe fundus abnormalities on examination, as well as a relatively high proportion of deleterious ABCA4 variants.

TL;DR: In this article, the authors performed full clinical examination and AF imaging in 68 patients with Stargardt disease and compared the baseline data to those at follow-up to calculate the rate of atrophy enlargement (RAE).

TL;DR: In this article, the authors investigated the clinical and electrophysiologic natural history of Stargardt disease and correlate with the genotype, and found that patients with initial rod ERG involvement demonstrated clinically significant electrophysisiologic deterioration; only 20% of patients with normal full-field ERGs at baseline showed clinically significant progression.

TL;DR: The presence of 2 distinct phenotypes of Stargardt disease (foveal sparing and foveal atrophy) suggests that there may be more than 1 disease mechanism in ABCA4 retinopathy.