K
Ke Ma
Researcher at Peking University
Publications - 8
Citations - 514
Ke Ma is an academic researcher from Peking University. The author has contributed to research in topics: Autophagy & FOXO1. The author has an hindex of 8, co-authored 8 publications receiving 432 citations.
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Journal ArticleDOI
Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62
Yanan Wang,Nan Zhang,Luyao Zhang,Ran Li,Wan Fu,Ke Ma,Xue Li,Lina Wang,Jiadong Wang,Hongquan Zhang,Wei Gu,Wei-Guo Zhu,Wei-Guo Zhu,Wei-Guo Zhu,Ying Zhao +14 more
TL;DR: It is reported that loss of autophagy is coupled to reduced histone H2A ubiquitination after DNA damage, and the complex relationship between Autophagy and the DNA damage response is highlighted.
Journal ArticleDOI
FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway
Jingyi Zhou,Wenjuan Liao,Jing Yang,Ke Ma,Xue Li,Yachen Wang,Donglai Wang,Lina Wang,Yu Zhang,Yuxin Yin,Ying Zhao,Wei-Guo Zhu +11 more
TL;DR: The results supported a mechanism whereby FOXO3 dramatically increased the expression of the class I PtdIns3K catalytic subunit PIK3CA, leading to an increase in AKT1 activity, which resulted in the phosphorylation and nuclear export of FOXO1.
Journal ArticleDOI
XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells.
Ying Zhao,Xue Li,Mu Yan Cai,Ke Ma,Jing Yang,Jingyi Zhou,Wan Fu,Fu Zheng Wei,Lina Wang,Dan Xie,Wei-Guo Zhu,Wei-Guo Zhu +11 more
TL;DR: It is reported that turnover of FoxO1 is involved in the dynamic autophagic process caused by glutamine starvation, and the dynamic process of autophagy is linked to XBP-1u-inducedFoxO1 degradation.
Journal ArticleDOI
Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death
TL;DR: It is demonstrated that FoxO1, a forkhead O family protein, is a mediator of autophagy that suppressed tumor xenograft growth in nude mice in an autophagic-dependent manner and is associated with tumor suppression function.
Journal ArticleDOI
Deficiency of hepatocystin induces autophagy through an mTOR-dependent pathway
Jing Yang,Ying Zhao,Ke Ma,Fen-Jun Jiang,Wenjuan Liao,Ping Zhang,Jingyi Zhou,Bo Tu,Lina Wang,Harm H. Kampinga,Zhiping Xie,Wei-Guo Zhu +11 more
TL;DR: It is demonstrated that knockdown of hepatocystin induces autophagy, the major intracellular degradation pathway essential for cellular health, and new insights are provided into the function of hepatocysin and the regulation ofAutophagy.