Keefe B. Manning

TL;DR: The fibrous PGS:PCL scaffolds seeded with human VICs mimick the structure and mechanical properties of native valve leaflet tissues and would potentially be suitable for the replacement of heart valves in diverse patient populations.

TL;DR: The aim is to describe work which pertains to the interaction between flow-induced stresses and the blood constituents, and that supports the hypothesis that thromboembolism in prosthetic blood recirculating devices is initiated and maintained primarily by the non-physiological flow patterns and stresses that activate and enhance the aggregation of blood platelets, increasing the risk of thrombogenic stroke.

TL;DR: The viscosity and elasticity of pediatric blood against shear rate for hematocrits from 19–56, measured using an oscillatory rheometer are presented and it is shown that when compared at constant hematOCrit, blood from adult and pediatric patients had similar viscoelastic properties.

TL;DR: Algorithms to investigate the wall shear-rates within the 50cc Penn State artificial heart using low magnification, conventional particle image velocimetry (PIV) and a zero masking and a fluid centroid shifting technique indicate that the size of the interrogation region should be chosen to be as small as possible to maximize resolution while large enough to ensure an adequate number of particles per region.

TL;DR: The regurgitant flow field of the St. Jude Medical bileaflet mechanical heart valve was assessed using PIV under physiologic pulsatile flow conditions and suggested little potential for hemolysis when the hinge jets collided, however, the vortex motion near the occluder tips potentially provides a low-pressure environment for cavitation.