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Keiichi Yamanaka
Researcher at Mie University
Publications - 181
Citations - 4140
Keiichi Yamanaka is an academic researcher from Mie University. The author has contributed to research in topics: Medicine & Atopic dermatitis. The author has an hindex of 25, co-authored 146 publications receiving 3646 citations. Previous affiliations of Keiichi Yamanaka include Brigham and Women's Hospital & Hyogo College of Medicine.
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Journal ArticleDOI
The Vast Majority of CLA+ T Cells Are Resident in Normal Skin
Rachael A. Clark,Benjamin F. Chong,Nina Mirchandani,Nooshin K. Brinster,Keiichi Yamanaka,Rebecca Dowgiert,Thomas S. Kupper +6 more
TL;DR: There are T cells within normal, noninflamed skin that most likely conduct immunosurveillance and are implicated in the development of psoriasis and it is estimated that 98% of CLA+ effector memory T cells are resident in normal skin under resting conditions.
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IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6.
Tomohiro Yoshimoto,Hitoshi Mizutani,Hiroko Tsutsui,Nancy Noben-Trauth,Keiichi Yamanaka,Minoru Tanaka,Shinzo Izumi,Haruki Okamura,William E. Paul,Kenji Nakanishi +9 more
TL;DR: IL-18, an IL-1–like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells−, IL-4– and STAT6–dependent fashion, providing a potential therapeutic target for allergic disorders.
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The Majority of Human Peripheral Blood CD4+CD25highFoxp3+ Regulatory T Cells Bear Functional Skin-Homing Receptors
Kazuki Hirahara,Luzheng Liu,Rachael A. Clark,Keiichi Yamanaka,Robert C. Fuhlbrigge,Thomas S. Kupper +5 more
TL;DR: The majority of true circulating Treg express functional skin-homing receptors, and human Treg may regulate local immune responses in normal human skin.
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IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions.
Hiroshi Konishi,Hiroko Tsutsui,Takaaki Murakami,Shizue Yumikura-Futatsugi,Keiichi Yamanaka,Minoru Tanaka,Yohichiro Iwakura,Noboru Suzuki,Kiyoshi Takeda,Shizuo Akira,Kenji Nakanishi,Hitoshi Mizutani +11 more
TL;DR: AD-like inflammation is initiated by overrelease of IL-18 and accelerated by IL-1, which might provide insight into understanding the pathogenesis of and establishing therapeutics for chronic inflammatory skin diseases including AD.
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A Novel Method for the Isolation of Skin Resident T Cells from Normal and Diseased Human Skin
Rachael A. Clark,Benjamin F. Chong,Nina Mirchandani,Keiichi Yamanaka,George F. Murphy,Rebecca Dowgiert,Thomas S. Kupper +6 more
TL;DR: This method allowed efficient isolation of malignant T cells from the skin lesions of cutaneous T cell lymphoma and the isolation of tumor-infiltrating lymphocytes from primary squamous cell carcinomas and melanoma metastases.