Showing papers in "Journal of Investigative Dermatology in 2006"

TL;DR: One approach to preventing or treating these ROS-mediated disorders is based on the administration of various antioxidants in an effort to restore homeostasis.

TL;DR: Lineage analysis demonstrated that all epithelial layers within the adult follicle and hair originated from bulge cells, and Bulge cells maintain their stem cell characteristics after propagation in vitro, thus ultimately they may be useful for tissue engineering applications.

TL;DR: The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous, and a predominance of stimulatory over inhibitory signals is required for effective immune responses to pathogens.

TL;DR: The "brain-skin connection," which may underlie inflammatory skin diseases triggered or aggravated by stress, is reviewed, and relevant general principles of skin neuroimmunology and neuroendocrinology are summarized.

TL;DR: Analysis of melanoma cell lines suggests that activating mutations in BRAF can occur simultaneously with inactivation of phosphatase and tensin homolog (PTEN), but neuroblastoma RAS (NRAS) mutations are not coincident, and the concurrent mutation of NRAS and BRAF was rare.

TL;DR: Investigation of the suitability of nanoparticles in transcutaneous vaccine administration found a high density of Langerhans cells around hair follicles that, when sorted, readily internalized all size particles, but not 750 or 1,500 nm nanoparticles, may be efficiently used.

TL;DR: Although patients with psoriasis have an increased relative risk of lymphoma, the absolute risk attributable to Psoriasis is low given that lymphoma is a rare disease and the magnitude of association is modest.

TL;DR: It is concluded that hollow microneedles can be used for precise microinjection into skin, especially when a single needle is inserted by rotary drilling and then retracted part way before infusion or a micronedle array is Inserted by mechanical vibration.

TL;DR: This review considers what has been discovered about the important cutaneous functions of γδ T cells through the study of mutant mice and offers perspectives on the roles ofγε T cells in human disease.

TL;DR: The presence of an autocrine adrenergic and cholinergic intra/intercellular signal transduction network in the human epidermis contributes significantly to homeostatic and compensatory responses regulating vital functions in keratinocytes and melanocytes.

TL;DR: This review summarizes the current information about the significance of neuron-skin interactions, ion channels, neuropeptides, proteases, cannabinoids, opioids, kinins, cytokines, biogenic amines, neurotransmitters, and their receptors in the pathobiology of pruritus.

TL;DR: Results demonstrate a prominent role for the epidermal barrier in atopic disease and have important implications for the study of complex traits.

TL;DR: Detailed knowledge about the phenotype and mode of action of Tregs will significantly increase the understanding of the pathogenesis of autoimmune diseases and will also help to identify new therapeutic strategies.

TL;DR: Scientific advances have provided surprising evidence that malignant tumors can directly promote lymphangiogenesis and lymphatic metastasis, and that lymphatic vessels play a major role in cutaneous inflammation and in the cutaneous response to UVB irradiation.

TL;DR: Interestingly, the phenotypes of individuals homozygous for R501X, 2282del4, or compound heterozygotes for R 501X and 3702delG, were comparable, suggesting that mutations located centrally in the filaggrin repeats are also pathogenic.

TL;DR: The findings indicate that the genetic factor on chromosome 6 has a strong influence on the phenotype of the disease, and underline that differences in clinical features of psoriasis may be to a large extent genetically determined.

TL;DR: The results demonstrate the importance of SP/SPI balance for normal permeable barrier homeostasis and identify PAR-2 as a novel signaling mechanism of permeability barrier, that is, of response linked to LB secretion.

TL;DR: The current state of knowledge of KC apoptosis is reviewed, with particular focus on apoptotic signaling pathways and molecular mechanisms of apoptosis control, and new insights into the complex role of apoptoses in skin carcinogenesis that are emerging from mouse models are discussed.

TL;DR: Gene expression profiling in acne patients indicates a prominent role of matrix metalloproteinases, inflammatory cytokines, and antimicrobial peptides in acne lesions.

TL;DR: It is hypothesized that melanoma develops from a mutated stem cell and therefore residual stem cell characteristics should be able to be identified in melanoma cell lines, and the ability to efflux Hoechst 33342 dye was used to segregate cell populations.

TL;DR: The SCORTEN performance during the first 5 days of hospitalization was excellent, and at its best on day 3, and the admission delay did not influence prognosis or SCORTen.

TL;DR: Progress in this field will likely result in novel therapies for the management of diseases characterized by deregulated inflammation, tissue remodeling, angiogenesis, and neoplasm.

TL;DR: Observations suggest that, in mammalian melanocytes, activation of the cKit receptor tyrosine kinase is primarily responsible for transmission of pro-migration signals, which may antagonize proliferation and melanogenesis.

TL;DR: This work further supports the implication of premature corneodesmosomal cadherin degradation in the pathogenesis of NS and provides evidence for additional factors playing a role in disease expression.

TL;DR: This method allowed efficient isolation of malignant T cells from the skin lesions of cutaneous T cell lymphoma and the isolation of tumor-infiltrating lymphocytes from primary squamous cell carcinomas and melanoma metastases.

TL;DR: Mechanistic basis for phenotypic variations in Netherton syndrome is provided, and compensatory mechanisms that permit survival of NS patients in the face of unrelenting SP attack are described.

TL;DR: Results suggest that nicotinic acid mediates its flushing side effect by interacting with GPR109A on skin Langerhans cells, resulting in release of PGD(2).

TL;DR: Members of the transient receptor potential (TRP) family are temperature sensors, and TRPV1, V3, and V4 are expressed in epidermal keratinocytes, and previous reports suggest the existence of a water flux sensor in the epidermis, and asTRPV4 is known to be activated by osmotic pressure, the results indicate that it might be this sensor.

TL;DR: Substantial evidence suggests that modulation of NT signalling by NTs receptor agonists/antagonists may be developed as intervention modalities in distinct skin and hair growth pathologies.

TL;DR: A unique gene expression signature for cutaneous SCC in humans is defined and potential roles for WNT, FZD, and PTN in the pathogenesis of SCC are suggested.