Nancy Noben-Trauth

TL;DR: In this paper, the authors investigated the mechanisms for down-regulation of cytotoxic T lymphocyte-mediated tumor immunosurveillance using a mouse model in which tumors show a growth-regression-recurrence pattern.

TL;DR: It is demonstrated that Stat6 signaling is not required for IL-4 enhancement of IgG1 production and actually inhibits IL- 4-induction of mucosal mastocytosis, and IL-13 may be more important thanIL-4 as an inducer of the Stat6 signaled signaling that leads to worm expulsion.

TL;DR: The studies reveal a dramatic exacerbating effect of SGS on lesion development in the dermal site, and a complete abrogation of this effect in mice preexposed to salivary components, the first to suggest that for individuals at risk of vector-borne infections, history of exposure to vector saliva might influence the outcome of Exposure to transmitted parasites.

TL;DR: IL-18, an IL-1–like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells−, IL-4– and STAT6–dependent fashion, providing a potential therapeutic target for allergic disorders.

TL;DR: Results indicate that an IL-4-independent, beta2-microglobulin-dependent pathway exists through which the CD62L-low CD4+ population has acquired IL- 4-producing capacity in vivo, strongly suggesting that these cells are NK T cells.