K
Keiko Mizuta
Researcher at Hiroshima University
Publications - 37
Citations - 801
Keiko Mizuta is an academic researcher from Hiroshima University. The author has contributed to research in topics: Ribosomal protein & Ribosome biogenesis. The author has an hindex of 17, co-authored 37 publications receiving 746 citations. Previous affiliations of Keiko Mizuta include Carnegie Mellon University.
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Journal ArticleDOI
RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae.
TL;DR: A cold-sensitive mutant with a mutation in a gene termed RRS1 (regulator of ribosome synthesis), which appeared to be defective in the signaling pathway, was isolated and greatly reduced transcriptional repression of both rRNA and ribosomal protein genes that is caused by a secretory defect.
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Ebp2p, yeast homologue of a human protein that interacts with Epstein-Barr virus nuclear antigen 1, is required for pre-rRNA processing and ribosomal subunit assembly.
Rota Tsujii,Keita Miyoshi,Akiko Tsuno,Yasushi Matsui,Akio Toh-e,Tokichi Miyakawa,Keiko Mizuta +6 more
TL;DR: A defect in the secretory pathway causes the transcriptional repression of both rRNA and ribosomal protein genes in Saccharomyces cerevisiae, suggesting a coupling of ribosome synthesis and plasma membrane synthesis.
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Normal assembly of 60 S ribosomal subunits is required for the signaling in response to a secretory defect in Saccharomyces cerevisiae.
Keita Miyoshi,Rota Tsujii,Hideji Yoshida,Yasushi Maki,Akira Wada,Yasushi Matsui,Akio Toh-e,Keiko Mizuta +7 more
TL;DR: Results suggest that signaling in response to a secretory defect requires the normal assembly of 60 S ribosomal subunits including Rrs1p and Rpl11p.
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Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB Pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae.
Daisuke Morita,Keita Miyoshi,Yasushi Matsui,Akio Toh-e,Hidenori Shinkawa,Tokichi Miyakawa,Keiko Mizuta +6 more
TL;DR: Northern, methionine pulse-chase, and sucrose density gradient ultracentrifugation analyses reveal that the depletion of Rpf2p results in a delayed processing of pre-rRNA, a decrease of mature 25 S rRNA, and a shortage of 60 S subunits.
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Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres
TL;DR: The results suggest that the ribosome biogenesis factors Ebp2 and Rrs1 cooperate with Mps3 to mediate telomere clustering, but not telomeres tethering, by binding Sir4.