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Shigetsugu Hatakeyama
Researcher at Hokkaido University
Publications - 162
Citations - 16064
Shigetsugu Hatakeyama is an academic researcher from Hokkaido University. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 58, co-authored 159 publications receiving 14686 citations. Previous affiliations of Shigetsugu Hatakeyama include Kyushu University & Howard Hughes Medical Institute.
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Journal ArticleDOI
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
Kevin L. Lorick,Jane P. Jensen,Shengyun Fang,Albert M. Ong,Shigetsugu Hatakeyama,Allan M. Weissman +5 more
TL;DR: It is suggested that a large number of RING finger-containing proteins, with otherwise diverse structures and functions, may play previously unappreciated roles in modulating protein levels via ubiquitination.
Journal ArticleDOI
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
Masayoshi Yada,Shigetsugu Hatakeyama,Takumi Kamura,Masaaki Nishiyama,Ryosuke Tsunematsu,Hiroyuki Imaki,Noriko Ishida,Fumihiko Okumura,Keiko Nakayama,Keiichi I. Nakayama +9 more
TL;DR: It is shown that the F‐box protein Fbw7 interacts with and thereby destabilizes c‐Myc in a manner dependent on phosphorylation of MB1, suggesting that two F‐ box proteins, FbW7 and Skp2, differentially regulate c‐ myc stability by targeting MB1 and MB2, respectively.
Journal ArticleDOI
Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication
Keiko Nakayama,Hiroyasu Nagahama,Yohji A. Minamishima,Masaki Matsumoto,Ikuo Nakamichi,Kyoko Kitagawa,Michiko Shirane,Ryosuke Tsunematsu,Tadasuke Tsukiyama,Noriko Ishida,Masatoshi Kitagawa,Keiichi I. Nakayama,Shigetsugu Hatakeyama +12 more
TL;DR: Results suggest that specific degradation of cyclin E and p27Kip1 is mediated by the SCFSkp2 ubiquitin ligase complex, and that Skp2 may control chromosome replication and centrosome duplication by determining the abundance of cell cycle regulators.
Journal ArticleDOI
TRIM proteins and cancer
TL;DR: This Review focuses on TRIM proteins that are involved in tumour development and progression.
Journal ArticleDOI
U Box Proteins as a New Family of Ubiquitin-Protein Ligases
TL;DR: Six mammalian U box proteins have now been shown to mediate polyubiquitination in the presence of E1 and E2 and in the absence of E3, suggesting that Ubox proteins constitute a third family of E4 enzymes and that E4 activity may reflect a specialized type of E2 activity.