Keith M. Sullivan

TL;DR: The primary dose limiting toxicity was pneumonitis, followed by veno-occlusive disease of the liver, renal impairment, and mucositis, and further investigation of regimens containing 16 Gy of hyperfractionated total body irradiation is warranted to assess anti-tumor efficacy.

TL;DR: The outcome of 13 patients with advanced malignancies who underwent nonmyeloablative conditioning therapy followed by infusion of partially matched unrelated cord blood cells and demonstrated donor chimerism provides a basis for further exploring this potentially curative approach to selected patients who lack matched related or unrelated hematopoietic stem cell donors.

TL;DR: Six fractionated total body irradiation regimens given over 2-7 days to a total midline dose of between 1200 and 1750 rads were evaluated in 41 patients with acute lymphoblastic leukemia in relapse, finding two of three disease-free survivors had significant graft-vs-host disease.

TL;DR: The data demonstrate that marrow transplantation can offer long-term survival for patients with FA, engraftment can be achieved with reduced doses of CY in FA patients, and less toxic preparative regimens are needed for FA patients who have developed leukemic transformation.

TL;DR: Joint Improvised Explosive Device Defeat Office (JIEDDO) J-9 Division and the Office of Naval Research (ONR) under Government Contract N000014-09-C-0419 and also NSF grant 0916870.