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Keith W. Dunaway
Researcher at University of California, Davis
Publications - 28
Citations - 923
Keith W. Dunaway is an academic researcher from University of California, Davis. The author has contributed to research in topics: DNA methylation & Epigenomics. The author has an hindex of 15, co-authored 28 publications receiving 672 citations. Previous affiliations of Keith W. Dunaway include University of California, Berkeley.
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Journal ArticleDOI
15q11.2–13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain
Dag H. Yasui,Haley A. Scoles,Shin-ichi Horike,Makiko Meguro-Horike,Keith W. Dunaway,Diane I. Schroeder,Janine M. LaSalle +6 more
TL;DR: Loss of long-range chromatin interactions within 15q11.2-13.3 may contribute to multiple human neurodevelopmental disorders, and transcription of CHRNA7 is modulated by Chromatin interactions with the PWS-IC.
Journal ArticleDOI
Population genetic screening efficiently identifies carriers of autosomal dominant diseases.
Joseph J. Grzymski,Joseph J. Grzymski,Gai Elhanan,J A Morales Rosado,E Smith,Karen Schlauch,Robert W Read,Chris Rowan,N Slotnick,S Dabe,William J. Metcalf,Bruce Lipp,H Reed,L Sharma,Elissa Levin,Jonathan C. Kao,Misha Rashkin,Johnathan Bowes,Keith W. Dunaway,Anthony D. Slonim,Nicole L. Washington,M Ferber,Alexandre Bolze,James T. Lu +23 more
TL;DR: Screening for a set of autosomal-dominant genetic conditions in a large, unselected cohort of individuals uncovers carriers who were missed by routine medical care, demonstrating the utility of broad genetic screening.
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Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation.
TL;DR: Phosphorylation is one of several factors that are important for interpreting the complexities of MeCP2 transcriptional modulation, including phosphorylation, acetylation, and ubiquitylation.
Journal ArticleDOI
MeCP2 modulates gene expression pathways in astrocytes
Dag H. Yasui,Huichun Xu,Huichun Xu,Keith W. Dunaway,Janine M. LaSalle,Lee-Way Jin,Izumi Maezawa +6 more
TL;DR: A set of potential MeCP2 target genes that may contribute to normal astrocyte signaling, cell division and neuronal support functions, the loss of which may contributing to the Rett syndrome phenotype are revealed.
Journal ArticleDOI
Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes
Keith W. Dunaway,M. Saharul Islam,Rochelle L. Coulson,S. Jesse Lopez,Annie Vogel Ciernia,Roy G. Chu,Dag H. Yasui,Isaac N. Pessah,Paul Lott,Charles E. Mordaunt,Makiko Meguro-Horike,Shin-ichi Horike,Ian F Korf,Janine M. LaSalle +13 more
TL;DR: It is found that significant global DNA hypomethylation is enriched over autism candidate genes and affects gene expression, demonstrating the compounding effects of genetic and environmental insults on the neuronal methylome that converge upon dysregulation of chromatin and synaptic genes.