M
Makiko Meguro-Horike
Researcher at Kanazawa University
Publications - 26
Citations - 776
Makiko Meguro-Horike is an academic researcher from Kanazawa University. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 12, co-authored 20 publications receiving 606 citations. Previous affiliations of Makiko Meguro-Horike include University of Tokushima.
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Journal ArticleDOI
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance
Masashi Yano,Noriyuki Kuroda,Hongwei Han,Makiko Meguro-Horike,Yumiko Nishikawa,Hiroshi Kiyonari,Kentaro Maemura,Yuchio Yanagawa,Kunihiko Obata,Satoru Takahashi,Tomokatsu Ikawa,Rumi Satoh,Hiroshi Kawamoto,Yasuhiro Mouri,Mitsuru Matsumoto +14 more
TL;DR: The results suggest that Aire controls the differentiation program of mTECs, thereby organizing the global mT EC integrity that enables TRA expression from terminally differentiated mTecs in the thymic microenvironment.
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15q11.2–13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain
Dag H. Yasui,Haley A. Scoles,Shin-ichi Horike,Makiko Meguro-Horike,Keith W. Dunaway,Diane I. Schroeder,Janine M. LaSalle +6 more
TL;DR: Loss of long-range chromatin interactions within 15q11.2-13.3 may contribute to multiple human neurodevelopmental disorders, and transcription of CHRNA7 is modulated by Chromatin interactions with the PWS-IC.
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Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes
Keith W. Dunaway,M. Saharul Islam,Rochelle L. Coulson,S. Jesse Lopez,Annie Vogel Ciernia,Roy G. Chu,Dag H. Yasui,Isaac N. Pessah,Paul Lott,Charles E. Mordaunt,Makiko Meguro-Horike,Shin-ichi Horike,Ian F Korf,Janine M. LaSalle +13 more
TL;DR: It is found that significant global DNA hypomethylation is enriched over autism candidate genes and affects gene expression, demonstrating the compounding effects of genetic and environmental insults on the neuronal methylome that converge upon dysregulation of chromatin and synaptic genes.
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Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Tatsunori Nishimura,Asuka Nakata,Xiaoxi Chen,Kurumi Nishi,Makiko Meguro-Horike,Soichiro Sasaki,Kenji Kita,Shin-ichi Horike,Kaori Saitoh,Keiko Kato,Kaori Igarashi,Takahiko Murayama,Susumu Kohno,Chiaki Takahashi,Naofumi Mukaida,Seiji Yano,Tomoyoshi Soga,Arinobu Tojo,Noriko Gotoh,Noriko Gotoh +19 more
TL;DR: MTHFD2-mediated mitochondrial 1C metabolism appears critical for cancer stem-like properties and resistance to drugs including gefitinib through consumption of A ICAR, leading to depletion of the intracellular pool of AICAR.
Journal ArticleDOI
Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome
Makiko Meguro-Horike,Dag H. Yasui,Weston T. Powell,Diane I. Schroeder,Mitsuo Oshimura,Janine M. LaSalle,Shin-ichi Horike +6 more
TL;DR: Data from a novel maternal 15q duplication neuronal model support a model where 15q11-q13 genes are regulated epigenetically at the level of both inter- and intra-chromosomal associations and that chromosome imbalance disrupts the epigenetic regulation of genes in 15q 11-q 13.