Kellie J. Sims

TL;DR: Simulations of metabolic fluxes, enzyme deletion and the effects of inositol led to predictions that show significant concordance with experimental results generated post hoc, demonstrating that modelling now allows testable predictions as well as the design and evaluation of hypothetical 'thought experiments' that may generate new metabolomic approaches.

TL;DR: Three integrative dynamical mathematical models of sphingolipid metabolism, designed as alternative power-law models within the framework of Biochemical Systems Theory, show dynamic responses to a variety of perturbations and changes in conditions that are essentially equivalent for small perturbation and similar for large perturbated conditions.

TL;DR: This review of sphingolipid metabolism in the budding yeast Saccharomyces cerevisiae contains information on the enzymes and the genes that encode them, as well as connections to other metabolic pathways.

TL;DR: The overall results show that Isc1p is an upstream regulator of Sit4p and implicate Sit4P activation in mitochondrial dysfunction leading to the shortened chronological lifespan and oxidative stress sensitivity of isc1Δ mutants.

TL;DR: The results indicate that yeast coordinates sphingolipid mediated changes during the diauxic shift through an array of small changes in many genes and enzymes, rather than relying on a strategy involving a few select genes with high sensitivity.