H
Hugo Osório
Researcher at University of Porto
Publications - 121
Citations - 3853
Hugo Osório is an academic researcher from University of Porto. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 25, co-authored 102 publications receiving 2843 citations. Previous affiliations of Hugo Osório include Intelligence and National Security Alliance & Spanish National Research Council.
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Journal ArticleDOI
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.
Haiying Zhang,Daniela Freitas,Han Sang Kim,Han Sang Kim,Kristina I. Fabijanic,Zhong Li,Haiyan Chen,Haiyan Chen,Milica Tesic Mark,Henrik Molina,Alberto Benito Martin,Linda Bojmar,Justin Fang,Sham Rampersaud,Ayuko Hoshino,Irina Matei,Candia M. Kenific,Miho Nakajima,Anders P. Mutvei,Pasquale Sansone,Weston Buehring,Huajuan Wang,Juan Pablo Jimenez,Leona Cohen-Gould,Navid Paknejad,Matthew Brendel,Katia Manova-Todorova,Ana Magalhães,José Alexandre Ferreira,Hugo Osório,André M. N. Silva,Ashish Massey,Juan R. Cubillos-Ruiz,Giuseppe Galletti,Paraskevi Giannakakou,Ana Maria Cuervo,John Blenis,Robert E. Schwartz,Mary Sue Brady,Héctor Peinado,Jacqueline Bromberg,Jacqueline Bromberg,Hiroshi Matsui,Celso A. Reis,David Lyden,David Lyden +45 more
TL;DR: It is shown that AF4 can serve as an improved analytical tool for isolating extracellular vesicles and addressing the complexities of heterogeneous nanoparticle subpopulations, and three nanoparticle subsets demonstrated diverse organ biodistribution patterns, suggesting distinct biological functions.
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Alterations in glycosylation as biomarkers for cancer detection
TL;DR: The application of these glycosylation modifications as biomarkers for cancer detection in tumour tissues and serological assays is summarised.
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Reactivity of Human Salivary Proteins Families Toward Food Polyphenols
Susana Soares,Rui Vitorino,Hugo Osório,Ana Luisa Godoy Fernandes,Armando Venâncio,Nuno Mateus,Francisco Amado,Victor de Freitas +7 more
TL;DR: Results obtained when all the main families of salivary proteins are present in a competitive assay, like in the oral cavity, demonstrate that condensed tannins interact first with acidic PRPs and statherin and thereafter with histatins, glycosylated PRPs, and bPRPs.
Journal ArticleDOI
Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa
Ana Magalhães,Joana Gomes,Mohd Nazri Ismail,Stuart M. Haslam,Nuno Mendes,Hugo Osório,Leonor David,Jacques Le Pendu,Rainer Haas,Anne Dell,Thomas Borén,Celso A. Reis +11 more
TL;DR: This study has used an animal model of nonsecretors, Fut2-null mice, to characterize the glycosylation profile and evaluate the effect of the observed glycan expression modifications in the process of H. pylori adhesion, and demonstrated expression of terminal difucosylated glycan structures.
Journal ArticleDOI
CNS involvement in V30M transthyretin amyloidosis: clinical, neuropathological and biochemical findings
Luis F. Maia,Rui Magalhães,Joel Freitas,Ricardo Taipa,Manuel Melo Pires,Hugo Osório,Daniel Dias,Helena Pessegueiro,Manuel Correia,Teresa Coelho +9 more
TL;DR: The findings indicate that CNS clinical involvement occurs in ATTR-V30M patients regardless of LT, and longer disease duration after LT can provide the necessary time for transthyretin amyloidosis to progress until it becomes clinically relevant.