K
Kelly-Ann Sheppard
Publications - 1
Citations - 627
Kelly-Ann Sheppard is an academic researcher. The author has contributed to research in topics: Phosphorylation & Immunoreceptor tyrosine-based inhibitory motif. The author has an hindex of 1, co-authored 1 publications receiving 543 citations.
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PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ
Kelly-Ann Sheppard,Lori Fitz,Julie M. Lee,Christina Benander,Judith A. George,Joe Wooters,Yongchang Qiu,Jason Jussif,Laura L. Carter,Clive Wood,Divya Chaudhary +10 more
TL;DR: It is demonstrated that PD‐1 modulation of T‐cell function involves inhibition of TCR‐mediated phosphorylation of ZAP70 and association with CD3ζ andPD‐1 signaling attenuates PKCθ activation loop phosphorylated in a cognate TCR signal.