D
Divya Chaudhary
Researcher at Genetics Institute, Inc.
Publications - 11
Citations - 3740
Divya Chaudhary is an academic researcher from Genetics Institute, Inc.. The author has contributed to research in topics: T-cell receptor & Phosphorylation. The author has an hindex of 6, co-authored 10 publications receiving 3344 citations. Previous affiliations of Divya Chaudhary include University of Michigan.
Papers
More filters
Journal ArticleDOI
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Yvette Latchman,Clive Wood,Tatyana Chernova,Divya Chaudhary,Madhuri Borde,Irene Chernova,Yoshiko Iwai,Andrew J. Long,Julia A. Brown,Raquel A. Nunes,Edward A. Greenfield,Karen Bourque,Vassiliki A. Boussiotis,Laura L. Carter,Beatriz M. Carreno,Nelly Malenkovich,Hiroyuki Nishimura,Taku Okazaki,Tasuku Honjo,Arlene H. Sharpe,Gordon J. Freeman +20 more
TL;DR: These studies show overlapping functions of PD-L1 andPD-L2 and indicate a key role for the PD- L–PD-1 pathway in regulating T cell responses.
Journal ArticleDOI
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ
Kelly-Ann Sheppard,Lori Fitz,Julie M. Lee,Christina Benander,Judith A. George,Joe Wooters,Yongchang Qiu,Jason Jussif,Laura L. Carter,Clive Wood,Divya Chaudhary +10 more
TL;DR: It is demonstrated that PD‐1 modulation of T‐cell function involves inhibition of TCR‐mediated phosphorylation of ZAP70 and association with CD3ζ andPD‐1 signaling attenuates PKCθ activation loop phosphorylated in a cognate TCR signal.
Journal ArticleDOI
Role of CED-4 in the activation of CED-3.
TL;DR: CED-4 induces CED-3 activation and subsequent apoptosis, and that the process requires binding of ATP, confirming that the nematode's cell-death apparatus is a multicomponent death complex.
Journal ArticleDOI
Catalytic Domain Crystal Structure of Protein Kinase C-θ (PKCθ) * ♦
Zhang-Bao Xu,Divya Chaudhary,Stephane Olland,Scott Wolfrom,Robert M. Czerwinski,Karl Malakian,Laura Lin,Mark Stahl,Diane Joseph-McCarthy,Christina Benander,Lori Fitz,Rita Greco,William S. Somers,Lidia Mosyak +13 more
TL;DR: The PKCθ-staurosporine complex represents the first kinase domain crystal structure of any PKC isotypes to be determined and as such should provide valuable insight into PKC specificity and into rational drug design strategies for PKC θ selective leads.
Journal ArticleDOI
The Death Inhibitory Molecules CED-9 and CED-4L Use a Common Mechanism to Inhibit the CED-3 Death Protease
TL;DR: The finding that CED-9 contacted the P-loop and selectively inhibited its interaction with the Ced-3 prodomain, providing a simple mechanism for how C ED-9 functions to block CED/CED-4-mediated CED’s3 processing and cell death.