K
Kelsey Breslin
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 24
Citations - 1055
Kelsey Breslin is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Epigenetics & Chromatin. The author has an hindex of 10, co-authored 19 publications receiving 879 citations.
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Journal ArticleDOI
Smchd1 haploinsufficiency exacerbates the phenotype of a transgenic FSHD1 mouse model.
Jessica C. de Greef,Yvonne D. Krom,Bianca den Hamer,Lauren Snider,Yosuke Hiramuki,Rob F. P. van den Akker,Kelsey Breslin,Miha Pakusch,Daniela C.F. Salvatori,Bram Slütter,Rabi Tawil,Marnie E. Blewitt,Marnie E. Blewitt,Stephen J. Tapscott,Silvère M. van der Maarel +14 more
TL;DR: The study emphasizes the evolutionary conservation of the SMCHD1-dependent epigenetic regulation of the D4Z4 repeat array and suggests that the D 4Z4-2.5/Smchd1MommeD1 mouse model may be used to unravel the function of DUX4 in non-muscle tissues like the skin.
Journal ArticleDOI
The long and the short of it: unlocking nanopore long-read RNA sequencing data with short-read differential expression analysis tools.
Xueyi Dong,Luyi Tian,Quentin Gouil,Hasaru Kariyawasam,Shian Su,Ricardo De Paoli-Iseppi,Yair David Joseph Prawer,Michael B. Clark,Kelsey Breslin,Megan Iminitoff,Marnie E. Blewitt,Charity W. Law,Matthew E. Ritchie +12 more
TL;DR: In this paper, the authors report the analysis of two nanopore RNA-seq datasets with the goal of obtaining gene-and isoform-level differential expression information, and compare results from the sequins dataset to the ground truth, and results of the mouse dataset to a previous short-read study on equivalent samples.
Posted ContentDOI
Long-range chromatin interactions on the inactive X and at Hox clusters are regulated by the non-canonical SMC protein Smchd1
Natasha Jansz,Andrew Keniry,Trussart M,Heidi Bildsoe,Tamara Beck,Ian D. Tonks,Arne W. Mould,Peter Hickey,Kelsey Breslin,Megan Iminitoff,Matthew E. Ritchie,Edwina McGlinn,Graham F. Kay,James M. Murphy,Marnie E. Blewitt +14 more
TL;DR: The non-canonical SMC protein Smchd1 is revealed as a novel regulator of long-range chromatin interactions, and it is added to the canon of epigenetic proteins required for Hox gene regulation.
Journal ArticleDOI
Maternal SMCHD1 regulates Hox gene expression and patterning in the mouse embryo
Natalia Benetti,Quentin Gouil,Andrés Tapia del Fierro,Tamara Beck,Kelsey Breslin,Andrew Keniry,Edwina McGlinn,Marnie E. Blewitt +7 more
TL;DR: In this paper , the epigenetic regulator SMCHD1 has a maternal effect on Hox gene expression and skeletal patterning, and it acts downstream of Polycomb marks to establish a chromatin state necessary for persistent epigenetic silencing and appropriate Hox genes expression later in the developing embryo.
Posted ContentDOI
SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease
Tapia del Fierro A,den Hamer B,Natasha Jansz,Kelan Chen,Tamara Beck,Hannah Vanyai,Benetti N,Alexandra D. Gurzau,Lucia Daxinger,Shifeng Xue,Nguyen Ly Tt,Wanigasuriya I,Kelsey Breslin,Harald Oey,Yvonne D. Krom,van der Hoorn D,Bouwman Lf,Matthew E. Ritchie,Bruno Reversade,Fabrice Prin,Timothy J. Mohun,van der Maarel Sm,Edwina McGlinn,James M. Murphy,Andrew Keniry,de Greef Jc,Marnie E. Blewitt +26 more
TL;DR: In this article, a point mutation in the non-canonical SMC protein SMCHD1 was reported to enhance its silencing capacity at endogenous developmental targets and at the facioscapulohumeral muscular dystrophy associated macro-array, D4Z4.