Y
Yoichi Minami
Researcher at Kyoto Prefectural University of Medicine
Publications - 36
Citations - 1236
Yoichi Minami is an academic researcher from Kyoto Prefectural University of Medicine. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 13, co-authored 33 publications receiving 1036 citations. Previous affiliations of Yoichi Minami include Kindai University.
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Journal ArticleDOI
Measurement of internal body time by blood metabolomics
Yoichi Minami,Takeya Kasukawa,Yuji Kakazu,Masayuki Iigo,Masahiro Sugimoto,Masahiro Sugimoto,Satsuki Ikeda,Akira Yasui,Gijsbertus T. J. van der Horst,Tomoyoshi Soga,Hiroki R. Ueda +10 more
TL;DR: The results suggest the potential for metabolomics-based detection of BT (“metabolite-timetable method”), which will lead to the realization of chronotherapy and personalized medicine.
Journal ArticleDOI
CKIε/δ-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock
Yasushi Isojima,Masato Nakajima,Hideki Ukai,Hiroshi Fujishima,Rikuhiro G. Yamada,Koh-hei Masumoto,Reiko Kiuchi,Mayumi Ishida,Maki Ukai-Tadenuma,Yoichi Minami,Ryotaku Kito,Kazuki Nakao,Wataru Kishimoto,Seung Hee Yoo,Seung Hee Yoo,Kazuhiro Shimomura,Toshifumi Takao,Atsuko Takano,Toshio Kojima,Katsuya Nagai,Yoshiyuki Sakaki,Joseph S. Takahashi,Joseph S. Takahashi,Hiroki R. Ueda +23 more
TL;DR: The degradation rate of PER2, which is regulated by CKIε/δ-dependent phosphorylation, was temperature-insensitive in living clock cells, yet sensitive to chemical perturbations, revealing its high sensitivity tochemical perturbation.
Journal ArticleDOI
Human blood metabolite timetable indicates internal body time
Takeya Kasukawa,Masahiro Sugimoto,Masahiro Sugimoto,Akiko Hida,Yoichi Minami,Masayo Mori,Sato Honma,Ken-ichi Honma,Kazuo Mishima,Tomoyoshi Soga,Hiroki R. Ueda +10 more
TL;DR: This work constructed a 1.5-d reference timetable of oscillating metabolites in human blood samples with 2-h sampling frequency and accurately determined internal body time within 3 h from just two anti-phase blood samples, enabling highly optimized and personalized medicine.
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Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles
Hiroki R. Ueda,Wenbin Chen,Yoichi Minami,Sato Honma,Ken-ichi Honma,Masamitsu Iino,Seiichi Hashimoto +6 more
TL;DR: The results demonstrate the feasibility of BT detection based on single-time-point sampling, suggest the potential for expression-based diagnosis of rhythm disorders, and may translate functional genomics into chronotherapy and personalized medicine.
Journal ArticleDOI
Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice
Hitoshi Inokawa,Yasuhiro Umemura,Akihiro Shimba,Eiryo Kawakami,Nobuya Koike,Yoshiki Tsuchiya,Munehiro Ohashi,Yoichi Minami,Guangwei Cui,Takuma Asahi,Ryutaro Ono,Yuh Sasawaki,Eiichi Konishi,Seung Hee Yoo,Zheng Chen,Satoshi Teramukai,Koichi Ikuta,Kazuhiro Yagita +17 more
TL;DR: The investigation of senescence-associated immune cell subsets from the spleens and mesenteric lymph nodes revealed an increase in PD-1 + CD44 high CD4 T cells as well as CD95 + GL7 + germinal center B cells, indicating that the long-term circadian misalignment exacerbates immune senescences and consequent chronic inflammation.