K
Kenishana Simpson
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 3
Citations - 923
Kenishana Simpson is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cancer & Cathepsin. The author has an hindex of 3, co-authored 3 publications receiving 708 citations.
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Journal ArticleDOI
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer
Tanaya Shree,Oakley C. Olson,Benelita T. Elie,Jemila C. Kester,Alfred L. Garfall,Kenishana Simpson,Katherine M. Bell-McGuinn,Emily C. Zabor,Edi Brogi,Johanna A. Joyce +9 more
TL;DR: Increased macrophage infiltration and cathepsin protease levels in mammary tumors following paclitaxel (Taxol) chemotherapy are found and this study highlights the importance of integrated targeting of the tumor and its microenvironment and implicates macrophages andCathepsins in blunting chemotherapeutic response.
Journal ArticleDOI
Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies
Robert L. Bowman,Florian Klemm,Florian Klemm,Florian Klemm,Leila Akkari,Leila Akkari,Leila Akkari,Stephanie M. Pyonteck,Lisa Sevenich,Daniela F. Quail,Surajit Dhara,Kenishana Simpson,Eric E. Gardner,Christine A. Iacobuzio-Donahue,Cameron Brennan,Viviane Tabar,Philip H. Gutin,Johanna A. Joyce,Johanna A. Joyce,Johanna A. Joyce +19 more
TL;DR: The data indicate that distinct transcriptional networks in brain-resident microglia and recruited BMDMs are associated with tumor-mediated education yet are also influenced by chromatin landscapes established before tumor initiation.
Journal ArticleDOI
Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors
Karen E. Hunter,Carmela Palermo,Jemila C. Kester,Kenishana Simpson,Jin-Ping Li,Laura H. Tang,David S. Klimstra,Israel Vlodavsky,Johanna A. Joyce +8 more
TL;DR: Elevated heparanase levels significantly increased peritumoral lymphangiogenesis in vivo and promoted the trans-differentiation of macrophages into lymphatic endothelial cell-like structures in culture, and it was found that heparinase deletion led to increased angiogenesis and pericyte coverage.