Experimental Neurology By Prof Paul Glees Pp xii + 532 (Oxford: Clarendon Press; London: Oxford University Press, 1961) 75s net

The Nervous System

State of the art in hair analysis for detection of drug and alcohol abuse.

Aims To examine the literature regarding clinical pharmacokinetics, direct effects and adverse clinical outcomes associated with methamphetamine use.

Methods  Relevant literature was identified through a PubMed search. Additional literature was obtained from relevant books and monographs.

Findings and conclusions  The mean elimination half-life for methamphetamine is approximately 10 hours, with considerable inter-individual variability in pharmacokinetics. Direct effects at low-to-moderate methamphetamine doses (5–30 mg) include arousal, positive mood, cardiac stimulation and acute improvement in cognitive domains such as attention and psychomotor coordination. At higher doses used typically by illicit users (≥50 mg), methamphetamine can produce psychosis. Its hypertensive effect can produce a number of acute and chronic cardiovascular complications. Repeated use may induce neurotoxicity, associated with prolonged psychiatric symptoms, cognitive impairment and an increased risk of developing Parkinson's disease. Abrupt cessation of repeated methamphetamine use leads to a withdrawal syndrome consisting of depressed mood, anxiety and sleep disturbance. Acute withdrawal lasts typically for 7–10 days, and residual symptoms associated with neurotoxicity may persist for several months.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1360-0443.2009.02564.x

A review of the clinical pharmacology of methamphetamine.

https://www.sjsu.edu/people/steven.lee/courses/c3/s2/New%20Non%20destructive%20confirmatory%20tests-1.pdf

Analysis of body fluids for forensic purposes: from laboratory testing to non-destructive rapid confirmatory identification at a crime scene.

A review of current trends and advances in modern bio-analytical methods: chromatography and sample preparation.

Genetic analysis of ryanodine receptor 1 gene and carnitine palmitoyltransferase II gene: an autopsy case of neuroleptic malignant syndrome related to vegetamin.

PROBLEM TO BE SOLVED: To provide a method for producing a carbon black having improved aggregate distribution characteristics, a high surface area, and high structure characteristics and an apparatus therefor. SOLUTION: A flat type spray apparatus is used for enhancing the contact efficiency between a high-temperature gas flow and a raw material hydrocarbon and for simultaneously homogenizing the reaction field in the carbon black formation reaction; and the spray angles of raw material introduction α, βare each set in a specified range.

Kenji Hara

Papers

Genetic analysis of ryanodine receptor 1 gene and carnitine palmitoyltransferase II gene: an autopsy case of neuroleptic malignant syndrome related to vegetamin.

Apparatus and method for producing carbon black

Application of wide-bore capillary gas chromatography to analyze volatile compounds in body fluids.

Quantification of immunohistochemical findings of neurofibrillary tangles and senile plaques for a diagnosis of dementia in forensic autopsy cases

Genetic analysis of the rhabdomyolysis-associated genes in forensic autopsy cases of methamphetamine abusers.