Experimental Neurology By Prof Paul Glees Pp xii + 532 (Oxford: Clarendon Press; London: Oxford University Press, 1961) 75s net

The Nervous System

State of the art in hair analysis for detection of drug and alcohol abuse.

Aims To examine the literature regarding clinical pharmacokinetics, direct effects and adverse clinical outcomes associated with methamphetamine use.

Methods  Relevant literature was identified through a PubMed search. Additional literature was obtained from relevant books and monographs.

Findings and conclusions  The mean elimination half-life for methamphetamine is approximately 10 hours, with considerable inter-individual variability in pharmacokinetics. Direct effects at low-to-moderate methamphetamine doses (5–30 mg) include arousal, positive mood, cardiac stimulation and acute improvement in cognitive domains such as attention and psychomotor coordination. At higher doses used typically by illicit users (≥50 mg), methamphetamine can produce psychosis. Its hypertensive effect can produce a number of acute and chronic cardiovascular complications. Repeated use may induce neurotoxicity, associated with prolonged psychiatric symptoms, cognitive impairment and an increased risk of developing Parkinson's disease. Abrupt cessation of repeated methamphetamine use leads to a withdrawal syndrome consisting of depressed mood, anxiety and sleep disturbance. Acute withdrawal lasts typically for 7–10 days, and residual symptoms associated with neurotoxicity may persist for several months.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1360-0443.2009.02564.x

A review of the clinical pharmacology of methamphetamine.

https://www.sjsu.edu/people/steven.lee/courses/c3/s2/New%20Non%20destructive%20confirmatory%20tests-1.pdf

Analysis of body fluids for forensic purposes: from laboratory testing to non-destructive rapid confirmatory identification at a crime scene.

A review of current trends and advances in modern bio-analytical methods: chromatography and sample preparation.

Association between cerebrospinal fluid dopamine concentrations and catechol-O-methyltransferase gene polymorphisms in forensic autopsy cases of methamphetamine abusers.

https://repo.lib.tokushima-u.ac.jp/files/public/11/112473/20181122135610146409/legalmed_36_81.pdf

Fatal accidental asphyxia in the reverse jack-knife position on a chair with wheels

VNTR polymorphism in the monoamine oxidase A promoter region and cerebrospinal fluid catecholamine concentrations in forensic autopsy cases

PROBLEM TO BE SOLVED: To provide a lithium secondary cell which can achieve both high output and long service life. SOLUTION: A lithium secondary cell 20 has a battery case 7 containing an electrode group 6 in which a positive electrode plate W1 and a negative electrode W3 are wounded on an axis 1 through a separator W5. The positive electrode plate W1 includes an aluminum foil as a positive collector, and a negative electrode plate W3 includes a rolled copper foil as a negative collector. In the positive electrode plate W1, a positive mix which contains a lithium-containing composite oxide is applied to both the sides of an aluminum foil. On the surface of the lithium-containing composite oxide, a conductive material and a lithium-containing additive are mechanochemically treated. The mechanochemically treated powder and a binder are blended into the positive mix. In the negative plate W3, a negative mix which contains an amorphous carbon material is applied to both the sides of the enrolled copper foil. The amorphous carbon material, the conductive material, and the binder are blended into the negative mix. COPYRIGHT: (C)2010,JPO&INPIT

Kenji Hara

Papers

Association between cerebrospinal fluid dopamine concentrations and catechol-O-methyltransferase gene polymorphisms in forensic autopsy cases of methamphetamine abusers.

Fatal accidental asphyxia in the reverse jack-knife position on a chair with wheels

VNTR polymorphism in the monoamine oxidase A promoter region and cerebrospinal fluid catecholamine concentrations in forensic autopsy cases

Lithium secondary cell

Diagnostic meaning of blood p-cresol concentration in forensic autopsy cases