K
Kenji Nagata
Researcher at University of Miyazaki
Publications - 44
Citations - 1113
Kenji Nagata is an academic researcher from University of Miyazaki. The author has contributed to research in topics: Hepatocellular carcinoma & Essential thrombocythemia. The author has an hindex of 17, co-authored 41 publications receiving 1020 citations.
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Journal ArticleDOI
Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F
Kotaro Shide,Haruko Shimoda,Takashi Kumano,Kennosuke Karube,Takuro Kameda,Katsuto Takenaka,Seido Oku,Hiroo Abe,Keiko Katayose,Youko Kubuki,Kazunori Kusumoto,Satoru Hasuike,Yoshihiro Tahara,Kenji Nagata,Tadashi Matsuda,Kouichi Ohshima,Mine Harada,Kazuya Shimoda +17 more
TL;DR: It is concluded that in vivo expression of JAK2 V617F results in ET-, PMF- and PV-like disease.
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Rat testosterone 7 alpha-hydroxylase. Isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene.
TL;DR: A P-450, designated P450a, with high testosterone 7 alpha-hydroxylase activity was purified from rat liver microsomes and a 1687-base pair cDNA was isolated and sequenced.
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TET2 is essential for survival and hematopoietic stem cell homeostasis.
Kotaro Shide,Takuro Kameda,Haruko Shimoda,Takumi Yamaji,Hiroo Abe,Ayako Kamiunten,Masaaki Sekine,Tomonori Hidaka,Keiko Katayose,Youko Kubuki,Shojiro Yamamoto,Tadashi Miike,Hisayoshi Iwakiri,Satoru Hasuike,Kenji Nagata,Kosuke Marutsuka,Atsushi Iwama,Tadashi Matsuda,Akira Kitanaka,Kazuya Shimoda +19 more
TL;DR: Data indicate that TET2 has a critical role in survival and HSC homeostasis, and TET1trap/trap HSCs exhibit an increased self-renewal ability in vivo.
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Calreticulin mutant mice develop essential thrombocythemia that is ameliorated by the JAK inhibitor ruxolitinib
Kotaro Shide,Takuro Kameda,Takumi Yamaji,Masaaki Sekine,N Inada,Ayako Kamiunten,Keiichi Akizuki,Kenichi Nakamura,Tomonori Hidaka,Yoko Kubuki,Haruko Shimoda,Akira Kitanaka,Arata Honda,Akira Sawaguchi,Hiroo Abe,Tadashi Miike,Hisayoshi Iwakiri,Yoshihiro Tahara,Mitsue Sueta,Satoru Hasuike,Shojiro Yamamoto,Kenji Nagata,Kazuya Shimoda +22 more
TL;DR: This study provides a model showing that the C-terminal of mutant CALR activated JAK-STAT signaling specifically downstream of MPL and may have a central role in CALR-induced myeloproliferative neoplasms.
Journal ArticleDOI
Increased rate of death related to presence of viremia among hepatitis C virus antibody–positive subjects in a community‐based cohort study
Hirofumi Uto,Sherri O. Stuver,Sherri O. Stuver,Katsuhiro Hayashi,Kotaro Kumagai,Fumisato Sasaki,Shuji Kanmura,Masatsugu Numata,Akihiro Moriuchi,Susumu Hasegawa,Makoto Oketani,Akio Ido,Kazunori Kusumoto,Satoru Hasuike,Kenji Nagata,Michinori Kohara,Hirohito Tsubouchi +16 more
TL;DR: The presence of viremia increases the rate of mortality, primarily due to liver‐related death, among anti–HCV‐seropositive persons in Japan.