T
Takuro Kameda
Researcher at University of Miyazaki
Publications - 52
Citations - 1941
Takuro Kameda is an academic researcher from University of Miyazaki. The author has contributed to research in topics: Leukemia & Adult T-cell leukemia/lymphoma. The author has an hindex of 12, co-authored 45 publications receiving 1528 citations.
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Journal ArticleDOI
Integrated molecular analysis of adult T cell leukemia/lymphoma
Keisuke Kataoka,Yasunobu Nagata,Akira Kitanaka,Yuichi Shiraishi,Teppei Shimamura,Jun-ichirou Yasunaga,Yasushi Totoki,Kenichi Chiba,Aiko Sato-Otsubo,Genta Nagae,Ryohei Ishii,Satsuki Muto,Shinichi Kotani,Yosaku Watatani,June Takeda,Masashi Sanada,Hiroko Tanaka,Hiromichi Suzuki,Yusuke Sato,Yusuke Shiozawa,Tetsuichi Yoshizato,Kenichi Yoshida,Hideki Makishima,Masako Iwanaga,Guangyong Ma,Kisato Nosaka,Masakatsu Hishizawa,Hidehiro Itonaga,Yoshitaka Imaizumi,Wataru Munakata,Hideaki Ogasawara,Toshitaka Sato,Ken Sasai,Kenzo Muramoto,Marina Penova,Takahisa Kawaguchi,Hiromi Nakamura,Natsuko Hama,Kotaro Shide,Yoko Kubuki,Tomonori Hidaka,Takuro Kameda,Tsuyoshi Nakamaki,Ken Ishiyama,Shuichi Miyawaki,Sung-Soo Yoon,Kensei Tobinai,Yasushi Miyazaki,Akifumi Takaori-Kondo,Fumihiko Matsuda,Kengo Takeuchi,Osamu Nureki,Hiroyuki Aburatani,Toshiki Watanabe,Tatsuhiro Shibata,Masao Matsuoka,Satoru Miyano,Kazuya Shimoda,Seishi Ogawa +58 more
TL;DR: The identified alterations overlap significantly with the HTLV-1 Tax interactome and are highly enriched for T cell receptor–NF-κB signaling, T cell trafficking and other T cell–related pathways as well as immunosurveillance.
Journal ArticleDOI
Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers
Keisuke Kataoka,Yuichi Shiraishi,Yohei Takeda,Seiji Sakata,Misako Matsumoto,Seiji Nagano,Takuya Maeda,Yasunobu Nagata,Akira Kitanaka,Seiya Mizuno,Hiroko Tanaka,Kenichi Chiba,Satoshi Ito,Yosaku Watatani,Nobuyuki Kakiuchi,Hiromichi Suzuki,Tetsuichi Yoshizato,Kenichi Yoshida,Masashi Sanada,Hidehiro Itonaga,Yoshitaka Imaizumi,Yasushi Totoki,Wataru Munakata,Hiromi Nakamura,Natsuko Hama,Kotaro Shide,Yoko Kubuki,Tomonori Hidaka,Takuro Kameda,Kyoko Masuda,Nagahiro Minato,Koichi Kashiwase,Koji Izutsu,Akifumi Takaori-Kondo,Yasushi Miyazaki,Satoru Takahashi,Tatsuhiro Shibata,Hiroshi Kawamoto,Yoshiki Akatsuka,Kazuya Shimoda,Kengo Takeuchi,Tsukasa Seya,Satoru Miyano,Seishi Ogawa +43 more
TL;DR: A unique genetic mechanism of immune escape caused by structural variations (SVs) commonly disrupting the 3' region of the PD-L1 gene is shown, supporting the role of relevant SVs in clonal selection through immune evasion and suggesting that PD-l1 3'-UTR disruption could serve as a genetic marker to identify cancers that actively evade anti-tumour immunity through PD- L1 overexpression.
Journal ArticleDOI
Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F
Kotaro Shide,Haruko Shimoda,Takashi Kumano,Kennosuke Karube,Takuro Kameda,Katsuto Takenaka,Seido Oku,Hiroo Abe,Keiko Katayose,Youko Kubuki,Kazunori Kusumoto,Satoru Hasuike,Yoshihiro Tahara,Kenji Nagata,Tadashi Matsuda,Kouichi Ohshima,Mine Harada,Kazuya Shimoda +17 more
TL;DR: It is concluded that in vivo expression of JAK2 V617F results in ET-, PMF- and PV-like disease.
Journal ArticleDOI
Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma.
Keisuke Kataoka,Masako Iwanaga,Jun-ichirou Yasunaga,Yasunobu Nagata,Akira Kitanaka,Takuro Kameda,Makoto Yoshimitsu,Yuichi Shiraishi,Aiko Sato-Otsubo,Masashi Sanada,Kenichi Chiba,Hiroko Tanaka,Yotaro Ochi,Kosuke Aoki,Hiromichi Suzuki,Yusuke Shiozawa,Tetsuichi Yoshizato,Yusuke Sato,Kenichi Yoshida,Kisato Nosaka,Masakatsu Hishizawa,Hidehiro Itonaga,Yoshitaka Imaizumi,Wataru Munakata,Kotaro Shide,Yoko Kubuki,Tomonori Hidaka,Tsuyoshi Nakamaki,Ken Ishiyama,Shuichi Miyawaki,Ryohei Ishii,Osamu Nureki,Kensei Tobinai,Yasushi Miyazaki,Akifumi Takaori-Kondo,Tatsuhiro Shibata,Satoru Miyano,Kenji Ishitsuka,Atae Utsunomiya,Kazuya Shimoda,Masao Matsuoka,Toshiki Watanabe,Seishi Ogawa +42 more
TL;DR: Somatic alterations characterizing aggressive diseases predict worse prognosis in indolent ATL, among which PD-L1 amplifications are a strong genetic predictor in both aggressive and indolENT ATL.
Journal ArticleDOI
TET2 is essential for survival and hematopoietic stem cell homeostasis.
Kotaro Shide,Takuro Kameda,Haruko Shimoda,Takumi Yamaji,Hiroo Abe,Ayako Kamiunten,Masaaki Sekine,Tomonori Hidaka,Keiko Katayose,Youko Kubuki,Shojiro Yamamoto,Tadashi Miike,Hisayoshi Iwakiri,Satoru Hasuike,Kenji Nagata,Kosuke Marutsuka,Atsushi Iwama,Tadashi Matsuda,Akira Kitanaka,Kazuya Shimoda +19 more
TL;DR: Data indicate that TET2 has a critical role in survival and HSC homeostasis, and TET1trap/trap HSCs exhibit an increased self-renewal ability in vivo.