T
Takashi Kumano
Researcher at Kyushu University
Publications - 5
Citations - 356
Takashi Kumano is an academic researcher from Kyushu University. The author has contributed to research in topics: Cell growth & Gene. The author has an hindex of 5, co-authored 5 publications receiving 336 citations.
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Journal ArticleDOI
Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F
Kotaro Shide,Haruko Shimoda,Takashi Kumano,Kennosuke Karube,Takuro Kameda,Katsuto Takenaka,Seido Oku,Hiroo Abe,Keiko Katayose,Youko Kubuki,Kazunori Kusumoto,Satoru Hasuike,Yoshihiro Tahara,Kenji Nagata,Tadashi Matsuda,Kouichi Ohshima,Mine Harada,Kazuya Shimoda +17 more
TL;DR: It is concluded that in vivo expression of JAK2 V617F results in ET-, PMF- and PV-like disease.
Journal ArticleDOI
Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis.
Koji Nagafuji,Atsushi Nonami,Takashi Kumano,Yoshikane Kikushige,Goichi Yoshimoto,Katsuto Takenaka,Kazuya Shimoda,Shouichi Ohga,Masaki Yasukawa,Hisanori Horiuchi,Eiichi Ishii,Mine Harada +11 more
TL;DR: In this article, a 62-year-old Japanese man with recurrent episodes of hemophagocytic lymphohistiocytosis (HLH) showed compound heterozygous mutation of perforin gene (PRF1) including deletion of two base pairs at codons 1090 and 1091 (1090-1091delCT) and guanine-to-adenine conversion at nucleotide position 916 (916GAEA).
Journal ArticleDOI
JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation.
Seido Oku,Katsuto Takenaka,Takuro Kuriyama,Kotaro Shide,Takashi Kumano,Yoshikane Kikushige,Shingo Urata,Takuji Yamauchi,Chika Iwamoto,Haruko Shimoda,Toshihiro Miyamoto,Koji Nagafuji,Junji Kishimoto,Kazuya Shimoda,Koichi Akashi +14 more
TL;DR: In this paper, the authors tried to separate the downstream signalling of JAK2 V617F to stimulate myeloproliferation and leucocyte alkaline phosphatase (LAP) activity.
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Distinctive expression of myelomonocytic markers and down-regulation of CD34 in acute myelogenous leukaemia with FLT3 tandem duplication and nucleophosmin mutation.
Yasuo Mori,Goichi Yoshimoto,Takashi Kumano,Toshihiro Miyamoto,Tadafumi Iino,Katsuto Takenaka,Hiromi Iwasaki,Naoki Harada,Naoko Kinukawa,Koji Nagafuji,Takanori Teshima,Kazuya Shimoda,Koichi Akashi,Mine Harada +13 more
TL;DR: Patients with acute myelogenous leukaemia (AML) show co‐existing frequently internal tandem duplications of FLT3 (FLT3‐ITD) and mutations of nucleophosmin (NPM1‐Mt).
Journal ArticleDOI
Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence
Kotaro Shide,Kazuya Shimoda,Kenjirou Kamezaki,Haruko Kakumitsu,Takashi Kumano,Akihiko Numata,Fumihiko Ishikawa,Katsuto Takenaka,Ken Yamamoto,Tadashi Matsuda,Mine Harada +10 more
TL;DR: The expression of V678F Tyk2 in Ba/F3 cells induced autonomous cell growth and showed hyper-responsiveness to IL-3, and no cases of ET patients lacking the V617F Jak2 mutation harbored theTyk2 mutation.