V
Vanessa Fontana
Researcher at State University of Campinas
Publications - 55
Citations - 1496
Vanessa Fontana is an academic researcher from State University of Campinas. The author has contributed to research in topics: Blood pressure & Enalapril. The author has an hindex of 18, co-authored 52 publications receiving 1214 citations. Previous affiliations of Vanessa Fontana include University of Liverpool & University of São Paulo.
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Journal ArticleDOI
DC isoketal-modified proteins activate T cells and promote hypertension
Annet Kirabo,Vanessa Fontana,Ana Paula Faria,Roxana Loperena,Christi L Galindo,Jing Wu,Alfiya T Bikineyeva,Sergey Dikalov,Liang Xiao,Wei Chen,Mohamed A. Saleh,Daniel W. Trott,Hana A. Itani,Antony Vinh,Venkataraman Amarnath,Kalyani Amarnath,Tomasz J. Guzik,Kenneth E. Bernstein,Xiao Z. Shen,Yu Shyr,Sheau-Chiann Chen,Raymond L. Mernaugh,Cheryl L. Laffer,Fernando Elijovich,Sean S. Davies,Heitor Moreno,Meena S. Madhur,L. Jackson Roberts,David G. Harrison +28 more
TL;DR: The data reveal that hypertension activates dendritic cell activation of T cells, in large part by promoting the formation of isoketals, and suggest that reducing isokets has potential as a treatment strategy for this disease.
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Spironolactone and hydrochlorothiazide exert antioxidant effects and reduce vascular matrix metalloproteinase-2 activity and expression in a model of renovascular hypertension
Carla S. Ceron,Michele M. Castro,Elen Rizzi,Marcelo F. Montenegro,Vanessa Fontana,Maria Cristina O. Salgado,Raquel F. Gerlach,Jose E. Tanus-Santos +7 more
TL;DR: This work examined whether treatment with spironolactone, hydrochlorothiazide or both drugs together modified hypertension‐induced changes in arterial blood pressure, aortic remodelling, vascular reactivity, oxidative stress and MMP levels and activity, in a model of renovascular hypertension.
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Increased arterial stiffness in resistant hypertension is associated with inflammatory biomarkers
Natalia R. Barbaro,Vanessa Fontana,Rodrigo Modolo,Ana Paula de Faria,Andréa Rodrigues Sabbatini,Francisco H. Fonseca,Gabriel Forato Anhê,Heitor Moreno +7 more
TL;DR: Findings suggest that inflammation plays a possible role in the pathophysiology of RHTN, which has higher levels of inflammatory cytokines as well as increased arterial stiffness, and detectable IL-1β levels are associated arterials stiffness.
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Circulating matrix metalloproteinases and their inhibitors in hypertension
TL;DR: The basic principles linking MMP activity with hypertension are reviewed, how antihypertensive drugs may affect MMPs and their endogenous inhibitors, i.e., tissue inhibitors of matrix metalloproteinases (TIMPs) are discussed.
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An update on the role of adipokines in arterial stiffness and hypertension.
TL;DR: This review aims to update the association between adipokines and arterial stiffness in essential and resistant hypertension (RHTN) and finds that adiponectin, leptin and resistin might be implicated in hypertension, as well as in vascular alterations associated with this condition.