V
Venkataraman Amarnath
Researcher at Vanderbilt University
Publications - 49
Citations - 1870
Venkataraman Amarnath is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Oxidative stress & Lipid peroxidation. The author has an hindex of 21, co-authored 43 publications receiving 1530 citations. Previous affiliations of Venkataraman Amarnath include Vanderbilt University Medical Center.
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Journal ArticleDOI
DC isoketal-modified proteins activate T cells and promote hypertension
Annet Kirabo,Vanessa Fontana,Ana Paula Faria,Roxana Loperena,Christi L Galindo,Jing Wu,Alfiya T Bikineyeva,Sergey Dikalov,Liang Xiao,Wei Chen,Mohamed A. Saleh,Daniel W. Trott,Hana A. Itani,Antony Vinh,Venkataraman Amarnath,Kalyani Amarnath,Tomasz J. Guzik,Kenneth E. Bernstein,Xiao Z. Shen,Yu Shyr,Sheau-Chiann Chen,Raymond L. Mernaugh,Cheryl L. Laffer,Fernando Elijovich,Sean S. Davies,Heitor Moreno,Meena S. Madhur,L. Jackson Roberts,David G. Harrison +28 more
TL;DR: The data reveal that hypertension activates dendritic cell activation of T cells, in large part by promoting the formation of isoketals, and suggest that reducing isokets has potential as a treatment strategy for this disease.
Journal ArticleDOI
4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites.
Matthew J. Picklo,Venkataraman Amarnath,J. Oliver McIntyre,Doyle G. Graham,Thomas J. Montine +4 more
TL;DR: In neurodegenerative disease, oxidative stress may impair mitochondrial respiration through the production of 4‐hydroxy‐2(E)‐nonenal (HNE), a lipophilic alkenal that forms stable adducts on mitochondrial proteins.
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Oxidative Mediated Lipid Peroxidation Recapitulates Proarrhythmic Effects on Cardiac Sodium Channels
Koji Fukuda,Sean S. Davies,Tadashi Nakajima,Boon Hooi Ong,Sabina Kupershmidt,Joshua P. Fessel,Venkataraman Amarnath,Mark E. Anderson,Penelope A. Boyden,Prakash C. Viswanathan,L. Jackson Roberts,Jeffrey R. Balser +11 more
TL;DR: It is shown here that oxidative stress reduces Na+ channel availability and synergistic functional effects of flecainide, a proarrhythmic Na+.
Journal ArticleDOI
Catalysis of catechol oxidation by metal-dithiocarbamate complexes in pesticides.
Vanessa A. Fitsanakis,Venkataraman Amarnath,Venkataraman Amarnath,Joshua T. Moore,Joshua T. Moore,Kathleen S. Montine,Kathleen S. Montine,Jing Zhang,Jing Zhang,Thomas J. Montine,Thomas J. Montine +10 more
TL;DR: The results point to the potential for manganese- and zinc-containing EBDC pesticides to promote oxidative stress in catecholaminergic regions of the brain.
Journal ArticleDOI
Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation.
James West,Chuan Ji,Stephen T. Duncan,Venkataraman Amarnath,Claus Schneider,Carmelo J. Rizzo,and Alan R. Brash,Lawrence J. Marnett +7 more
TL;DR: The results presented herein suggest that 4-HPNE, 4-ONE, and 4-HNE commonly activate certain signaling pathways that control cell death irrespective of their reactive properties.