K
Kenneth H. Wolfe
Researcher at University College Dublin
Publications - 206
Citations - 50461
Kenneth H. Wolfe is an academic researcher from University College Dublin. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 80, co-authored 195 publications receiving 47190 citations. Previous affiliations of Kenneth H. Wolfe include University of Texas Health Science Center at Houston & University of Sydney.
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Evolution of gene order and chromosome number in Saccharomyces, Kluyveromyces and related fungi.
TL;DR: Analysis of gene order arrangements, chromosome numbers, and ribosomal RNA sequences suggests that genome duplication occurred before the divergence of the four species in Saccharomyces sensu stricto, but after this lineage had diverged from SacCharomyces kluyveri and the Kluyveromyces lactis/marxianus species assemblage.
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Consistent Patterns of Rate Asymmetry and Gene Loss Indicate Widespread Neofunctionalization of Yeast Genes After Whole-Genome Duplication
Kevin P. Byrne,Kenneth H. Wolfe +1 more
TL;DR: Results suggest that a significant fraction of the retained ohnologs in yeast species underwent neofunctionalization soon after duplication, which indicates that the evolutionary rate differences were established before speciation and hence soon after the WGD.
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Comparative Genome Analysis and Gene Finding in Candida Species Using CGOB
Sarah Maguire,Seán S. ÓhÉigeartaigh,Kevin P. Byrne,Markus S. Schröder,Peadar O'Gaora,Kenneth H. Wolfe,Geraldine Butler +6 more
TL;DR: The Candida Gene Order Browser was developed as a tool to visualize and analyze synteny relationships in multiple Candida species, and to provide an accurate, manually curated set of orthologous Candida genes for evolutionary analyses, and the underlying structure of the database has been changed significantly.
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Physiological and metabolic diversity in the yeast Kluyveromyces marxianus
Melanie M. Lane,Niall Burke,Rob Karreman,Kenneth H. Wolfe,Conor P. O'Byrne,John P. Morrissey +5 more
TL;DR: It was found that K. marxianus can exist as stable haploid or diploid cells, opening up additional prospects for future strain engineering and indicating that it should be possible to identify the molecular basis of traits to facilitate selection or engineering of strains adapted for industrial environments.
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Not Born Equal: Increased Rate Asymmetry in Relocated and Retrotransposed Rodent Gene Duplicates
Brian P. Cusack,Kenneth H. Wolfe +1 more
TL;DR: It is found that most young rodent duplicates that have been relocated were created by Retrotransposition, and it is demonstrated that the faster sequence evolution of retrogenes correlates with the profound alteration of their expression pattern that is precipitated by retrotransposition.