Kenneth Henry

TL;DR: It is shown that TSC2 protein can bind and selectively modulate transcription mediated by members of the steroid receptor superfamily of genes, which strengthens the expanding body of evidence that these coregulators may play critical roles in cellular differentiation.

TL;DR: Deletion of the LDL receptor-related protein-1 gene in Schwann cells induces abnormalities in axon myelination and in ensheathment of axons by nonmyelinating Schwann Cells in Remak bundles, which identify LRP1 as an essential mediator of normal Schwann cell–axonal interactions and as a pivotal regulator of the Schwanncell response to PNS injury in vivo.

TL;DR: Severe T3 SCI successfully models persistent pain states and could constitute a useful model system for examining candidate translational pain therapies after SCI, indicating that aberrant pain fiber sprouting and gliopathy occur after severe SCI.

TL;DR: LRP1 functions as a potent activator of PI3K in SCs and, by this mechanism, limits SC apoptosis resulting from increased CHOP expression in nerve injury, which supports a model in which UPR-activated signaling pathways represent a major challenge to SC survival in nerve injuries.

TL;DR: Treatment of adult rat dorsal root ganglion neurons in vitro with LRP1 agonists induces TrkC, Akt, and ERK activation; significantly increases neurite outgrowth; and overcomes myelin inhibition, identifying a novel class of therapeutic targets to explore for traumatic neurological disorders.