K
Kenneth I. Welsh
Researcher at Imperial College London
Publications - 188
Citations - 13103
Kenneth I. Welsh is an academic researcher from Imperial College London. The author has contributed to research in topics: Human leukocyte antigen & Allele. The author has an hindex of 60, co-authored 188 publications receiving 12704 citations. Previous affiliations of Kenneth I. Welsh include John Radcliffe Hospital & St. Vincent's Health System.
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Journal ArticleDOI
Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP)
Michael Bunce,C. M. O'Neill,Martin Barnardo,P. Krausa,M. J. Browning,Peter J. Morris,Kenneth I. Welsh +6 more
TL;DR: The Phototyping set has been used as the sole method of HLA typing for over 1010 individuals and has capacity to detect new alleles, for example, novel amplification patterns suggestive of 4 new HLA-B alleles have been detected.
Journal ArticleDOI
Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12.
Jack Satsangi,Miles Parkes,Edouard Louis,L Hashimoto,N Kato,Kenneth I. Welsh,Joseph D. Terwilliger,Joseph D. Terwilliger,G M Lathrop,John I. Bell,John I. Bell,Derek P. Jewell +11 more
TL;DR: The data suggest that CD and UC are closely related, but distinct, polygenic disorders that share some, but not all, susceptibility genes.
Journal ArticleDOI
HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy
Katie Jeffery,Koichiro Usuku,Sarah E. Hall,Wataru Matsumoto,Graham P. Taylor,J. Procter,Michael Bunce,Graham S. Ogg,Kenneth I. Welsh,Jonathan Weber,Alun L. Lloyd,Martin A. Nowak,Masahiro Nagai,Daisuke Kodama,Shuji Izumo,Mitsuhiro Osame,Charles R. M. Bangham +16 more
TL;DR: It is shown that, after infection with HTLV-I, the class I allele HLA-A*02 halves the odds of HAM/TSP, implying that an efficient antiviral CTL response can reduce virus load and so prevent disease in persistent virus infections.
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HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.
B. P. Wordsworth,Jerry S. Lanchbury,Lazaros I. Sakkas,Kenneth I. Welsh,Gabriel S. Panayi,John I. Bell +5 more
TL;DR: Sequencing the DRB1 and DQB1 genes from RA patients provides direct evidence that sequence differences between these subtypes implicate those residues around the putative antigen binding site of the DR beta molecule in the pathogenesis of RA.
Journal ArticleDOI
Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease.
TL;DR: Genes of the major histocompatibility complex are implicated as important inherited determinants of susceptibility to ulcerative colitis and may also influence the pattern of disease.