K
Kenneth L. Kirk
Researcher at National Institutes of Health
Publications - 302
Citations - 9584
Kenneth L. Kirk is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Receptor & Adenosine. The author has an hindex of 45, co-authored 302 publications receiving 9100 citations. Previous affiliations of Kenneth L. Kirk include Tokushima Bunri University.
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Journal ArticleDOI
Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments
TL;DR: Methods for introducing fluorine into organic molecules are reviewed, with an emphasis on preparation of compounds designed for biomedicinal applications.
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Fluorine in medicinal chemistry: Recent therapeutic applications of fluorinated small molecules
TL;DR: Fluorinated drugs for treatment of diseases of the central nervous system, various cardiovascular diseases and obesity, antibacterial agents, and antifungal therapy are reviewed.
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Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.
Qi Chen,Michael Graham Espey,Andrew Y. Sun,Chaya Pooput,Kenneth L. Kirk,Murali C. Krishna,Deena Beneda Khosh,Jeanne Drisko,Mark Levine +8 more
TL;DR: It is shown that ascorbate at pharmacologic concentrations was a prooxidant, generating hydrogen-peroxide-dependent cytotoxicity toward a variety of cancer cells in vitro without adversely affecting normal cells, and this action may have benefits in cancers with poor prognosis and limited therapeutic options.
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Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.
Qi Chen,Michael Graham Espey,Andrew Y. Sun,Je-Hyuk Lee,Murali C. Krishna,Emily Shacter,Peter L. Choyke,Chaya Pooput,Kenneth L. Kirk,Garry R. Buettner,Mark Levine +10 more
TL;DR: The data show that pharmacologic ascorbate is a prodrug for preferential steady-state formation of Asc•− and H2O2 in the extracellular space but not blood, which provides a foundation for pursuing pharmacological ascorBate as a prooxidant therapeutic agent in cancer and infections.
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Simultaneous determination of 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detection
TL;DR: The use of ascorbate as a preserving agent for monoamine metabolites in CSF was not found to be necessary when proper care was exercised in sample handling and storage.