K
Kenneth P. Nephew
Researcher at Indiana University
Publications - 284
Citations - 17018
Kenneth P. Nephew is an academic researcher from Indiana University. The author has contributed to research in topics: Ovarian cancer & DNA methylation. The author has an hindex of 66, co-authored 267 publications receiving 15106 citations. Previous affiliations of Kenneth P. Nephew include University of Tennessee Health Science Center & Indiana University – Purdue University Indianapolis.
Papers
More filters
Book ChapterDOI
Application of Next-Generation Sequencing to Analysis of TGFβ/SMAD4 Targets in Ovarian Cancer
TL;DR: The utility of next-generation sequencing technology to identify genome-wide SMAD4 target genes in epithelial ovarian cancer and link aberrant TGFβ/SMAD signaling to ovarian tumorigenesis is highlighted.
Posted ContentDOI
Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2
Weining Wang,Yanchi Zhou,Ji Wang,Shu Yun Zhang,Ali Rayet Ozes,Hongyu Gao,Fang Fang,Yue Wang,Xiaona Chu,Yunlong Liu,Jun Wang,Anirban K. Mitra,Heather M. O'Hagan,Kenneth P. Nephew +13 more
TL;DR: In this article , the authors used paired CRISPR guide RNA design to investigate the function of HOXC transcript antisense RNA (HOTAIR) and showed that loss of HOTAIR function re-sensitized cancer cells to platinum treatment and decreased the population of cancer stem cells.
Journal ArticleDOI
A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways.
Margarite D. Matossian,Hope E. Burks,Steven Elliott,Van T. Hoang,William J. Zuercher,Carrow I. Wells,David H. Drewry,Nirav Kapadia,Tiffany R. Chang,Thomas J. Yan,Gabrielle O. Windsor,Khoa Nguyen,Fang Fang,Kenneth P. Nephew,Aaron Buechlein,Douglas B. Rusch,Rachel A. Sabol,Rachel A. Sabol,Deniz A. Ucar,Jovanny Zabaleta,Lucio Miele,Bruce A. Bunnell,Bridgette M. Collins-Burow,Matthew E. Burow +23 more
TL;DR: A new method for discovering novel kinase targets that reverse the EMT phenotype is introduced; this screening approach can be applied to all cancer types and is not limited to breast cancer.
Posted ContentDOI
HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5
Curt Jacobs,Sakhi Shah,Wen Cheng Lu,Haimanti Ray,John Wang,Kenneth P. Nephew,Xin Liu,Sha Cao,Richard L. Carpenter +8 more
TL;DR: In this article , the authors showed a model whereby HSF1 suppresses CCL5 leading to reduced CD8+ T cells in breast tumors that prevented immune-mediated destruction.
Book ChapterDOI
Chapter 3 – Epigenetics
TL;DR: The OC epigenome is implicated in tumor progression, development of chemotherapy resistance, persistence, and survival of cancer stem cells, and will become an important new therapeutic cancer target as the machinery governing epigenetic changes is being deciphered.