K
Kenneth P. Nephew
Researcher at Indiana University
Publications - 284
Citations - 17018
Kenneth P. Nephew is an academic researcher from Indiana University. The author has contributed to research in topics: Ovarian cancer & DNA methylation. The author has an hindex of 66, co-authored 267 publications receiving 15106 citations. Previous affiliations of Kenneth P. Nephew include University of Tennessee Health Science Center & Indiana University – Purdue University Indianapolis.
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Journal Article
New anti-cancer strategies
Posted ContentDOI
Novel epigenetic-metabolic inhibitor combination treatment blocks platinum-induced ovarian cancer stem cell enrichment
Riddhi Sood,Xiao S,Shruthi Sriramkumar,Christiane Hassel,Kenneth P. Nephew,Heather M. O'Hagan +5 more
TL;DR: In this article, the authors demonstrated that acute platinum treatment induced a DNA damage-dependent decrease in BRCA1 levels through BRCCA1 promoter DNA hypermethylation, and increased expression of NAMPT, the rate limiting regulator of NAD+ production from the salvage pathway.
Journal Article
Dysregulation of TGFβ/Smad4 signaling and contribution of a CpG island methylator phenotype in ovarian cancer
Michael W.Y. Chan,Pearlly S. Yan,Junghee Han,Anne P G Crijns,Alfred S. L. Cheng,Joseph Liu,Daniela Matei,Zailong Wang,Sandya Liyanarachchi,Irene P. Joseph Souriraj,Hao Sun,Rachel A. Jansen,Dustin Potter,Shili Lin,Ate G.J. van der Zee,Robert M Brown,Ramana V. Davuluri,Kenneth P. Nephew,Joel H. Saltz,Tim H-M Huang +19 more
TL;DR: This study combined both chromatin immunoprecipitation microarray (ChIP-chip) and differential methylation hybridization (DMH) to investigate this epigenetic mechanism in ovarian cancer and found patients with high degrees of concurrent hypermethylation had significantly shorter progression-free survival.
Book ChapterDOI
Complete Transcriptome RNA-Seq
David F.B. Miller,Pearlly S. Yan,Fang Fang,Aaron Buechlein,Karl Kroll,David Frankhouser,Cameron L. Stump,Paige A. Stump,James Ford,Haixu Tang,Scott D. Michaels,Daniela Matei,Tim H M Huang,Jeremy Chien,Yunlong Liu,Douglas B. Rusch,Kenneth P. Nephew +16 more
TL;DR: This protocol utilizes duplex-specific nuclease (DSN) to remove abundant ribosomal RNA sequences while retaining other types of RNA for superior transcriptome profiling from low quantity input.
Journal ArticleDOI
ZEB2 regulates endocrine therapy sensitivity and metastasis in luminal a breast cancer cells through a non-canonical mechanism.
Hope E. Burks,Margarite D. Matossian,Lyndsay V. Rhodes,Theresa B. Phamduy,Steven Elliott,Aaron Buechlein,Douglas B. Rusch,David F.B. Miller,Kenneth P. Nephew,Douglas B. Chrisey,Bridgette M. Collins-Burow,Matthew E. Burow +11 more
TL;DR: ZEB2 is a multi-functional regulator of drug sensitivity, cell migration and metastasis in ER+ breast cancer and functions through non-canonical mechanisms.