K
Kenneth P. Nephew
Researcher at Indiana University
Publications - 284
Citations - 17018
Kenneth P. Nephew is an academic researcher from Indiana University. The author has contributed to research in topics: Ovarian cancer & DNA methylation. The author has an hindex of 66, co-authored 267 publications receiving 15106 citations. Previous affiliations of Kenneth P. Nephew include University of Tennessee Health Science Center & Indiana University – Purdue University Indianapolis.
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GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response
Baishen Chen,Baishen Chen,Xi Rao,Michael G. House,Kenneth P. Nephew,Kevin J. Cullen,Zhongmin Guo +6 more
TL;DR: These findings support the hypothesis that defects in the antioxidant system may contribute to tumorigenesis of a wide spectrum of human malignancies and may have implications in chemotherapy response and clinical outcome of HNC patients.
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Identifying estrogen receptor α target genes using integrated computational genomics and chromatin immunoprecipitation microarray
Victor X. Jin,Yu-Wei Leu,Sandya Liyanarachchi,Hao Sun,Meiyun Fan,Kenneth P. Nephew,Tim H M Huang,Ramana V. Davuluri +7 more
TL;DR: The integrated approach sets a paradigm in which the iterative process of model refinement and experimental verification will continue until an accurate prediction of promoter target sequences is derived, and 20 loci upregulated in an ERalpha-positive breast cancer cell line were correctly predicted by CART.
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Genomic and epigenomic signatures in ovarian cancer associated with resensitization to platinum drugs
Fang Fang,Horacio Cardenas,Hao Huang,Guanglong Jiang,Susan M. Perkins,Chi Zhang,Harold N. Keer,Yunlong Liu,Kenneth P. Nephew,Kenneth P. Nephew,Daniela Matei,Daniela Matei +11 more
TL;DR: In this article, an epigenetic signature associated with platinum drug resensitization that may offer utility in predicting the outcomes of patients who are coadministered a DNA methyltransferase inhibitor was elucidated.
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Definition of a FoxA1 Cistrome That Is Crucial for G1 to S-Phase Cell-Cycle Transit in Castration-Resistant Prostate Cancer
Chunpeng Zhang,Liguo Wang,Dayong Wu,Hongyan Chen,Zhong Chen,Jennifer M. Thomas-Ahner,Debra L. Zynger,Jérôme Eeckhoute,Jindan Yu,Jun Luo,Myles Brown,Steven K. Clinton,Kenneth P. Nephew,Tim H M Huang,Wei Li,Qianben Wang +15 more
TL;DR: These findings establish FoxA1 as a pivotal driver of the cell-cycle in CRPC which promotes G₁ to S-phase transit as well as G⁁ to M-phase Transit through two distinct mechanisms.
TGF-β induces global changes in DNA methylation during the epithelial-to-mesenchymal transition in ovarian cancer cells
Horacio Cardenas,Edyta Vieth,Jiyoon Lee,Mathew Segar,Yunlong Liu,Kenneth P. Nephew,Daniela Matei +6 more
TL;DR: Cardenas et al. as mentioned in this paper showed that TGF-β induces global changes in DNA methylation during the epithelial-to-mesenchymal transition in ovarian cancer cells.