Kerstin K. Landrock

TL;DR: The hypothesis that cytoplasmic lipid binding proteins transfer and channel lipidic ligands into nuclei for initiating nuclear receptor transcriptional activity to provide new lipid nutrient signaling pathways that affect lipid and glucose catabolism and storage is proposed.

TL;DR: Despite the absence of caveolin-1 in liver hepatocytes, lipid rafts represented nearly one-third of the mouse hepatocyte plasma membrane proteins and displayed unique protein, lipid, and biophysical properties that were differentially regulated by SCP-2 expression.

TL;DR: FABP1 gene ablation significantly increased hepatic levels of AEA, 2-AG, and 2-OG and indicated that FABP 1 not only is the most prominent endocannabinoid and cannabinoid binding protein but also impacts hepatic endoc cannabinoid levels.

TL;DR: L-FABP gene ablation decreased fat oxidation and sensitized all mice to weight gain as whole body FTM and LTM—with the most gain observed in FTM of control vs high-fat fed female L-FabP null mice.

TL;DR: Resolving human FABP1 and the T94A variant’s impact on the endocannabinoid and cannabinoid system is an exciting challenge due to the importance of this system in hepatic lipid accumulation as well as behavior, pain, inflammation, and satiety.