K
Ketan R. Patel
Researcher at University of Leicester
Publications - 12
Citations - 2712
Ketan R. Patel is an academic researcher from University of Leicester. The author has contributed to research in topics: Resveratrol & Pharmacokinetics. The author has an hindex of 9, co-authored 12 publications receiving 2449 citations. Previous affiliations of Ketan R. Patel include University of Michigan & Leicester Royal Infirmary.
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Journal ArticleDOI
Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
David J. Boocock,Guy Faust,Ketan R. Patel,Anna M. Schinas,Victoria Brown,Murray P. Ducharme,Tristan D. Booth,James A. Crowell,Marjorie Perloff,Andreas J. Gescher,William P. Steward,Dean E. Brenner +11 more
TL;DR: The results presented here intimate that consumption of high-dose resveratrol might be insufficient to elicit systemic levels commensurate with cancer chemopreventive efficacy, however, the high systemic levels of resver atrol conjugate metabolites suggest that their cancer chemosynthetic properties warrant investigation.
Journal ArticleDOI
Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics and Effect on the Insulin-like Growth Factor Axis
Victoria A. Brown,Ketan R. Patel,Maria Viskaduraki,James A. Crowell,Marjorie Perloff,Tristan D. Booth,Grygoriy Vasilinin,Ananda Sen,Anna M. Schinas,Gianfranca Piccirilli,Karen Brown,William P. Steward,Andreas J. Gescher,Dean E. Brenner +13 more
TL;DR: It is suggested that repeated administration of high doses of resveratrol generates micromolar concentrations of parent and much higher levels of glucuronide and sulfate conjugates in the plasma, which might contribute to cancer chemopreventive activity.
Journal ArticleDOI
Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients
Ketan R. Patel,Victoria A. Brown,Donald J. L. Jones,Robert G. Britton,David Hemingway,Andrew S. Miller,Kevin West,Tristan D. Booth,Marjorie Perloff,James A. Crowell,Dean E. Brenner,William P. Steward,Andreas J. Gescher,Karen Brown +13 more
TL;DR: Resveratrol merits further clinical evaluation as a potential colorectal cancer chemopreventive agent after it was found to be well tolerated and to produce levels in the human gastrointestinal tract of an order of magnitude sufficient to elicit anticarcinogenic effects.
Journal ArticleDOI
Clinical trials of resveratrol
Ketan R. Patel,Edwina N. Scott,Victoria A. Brown,Andreas J. Gescher,William P. Steward,Karen Brown +5 more
TL;DR: The occurrence of mild to moderate side effects is likely to limit the doses employed in future trials to significantly less than this amount, and what additional information is needed is suggested to increase the chances of success in future clinical trials.
Journal ArticleDOI
Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography
David J. Boocock,Ketan R. Patel,Guy Faust,Daniel P. Normolle,Timothy H. Marczylo,James A. Crowell,Dean E. Brenner,Tristan D. Booth,Andreas J. Gescher,William P. Steward +9 more
TL;DR: A reversed-phase HPLC method that uses gradient elution and UV detection (325 nm) to determine levels of resveratrol and identify six major conjugated metabolites in the plasma and urine of human volunteers after administration of a single oral dose of 1g is described.