Karen Brown

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is suggested that repeated administration of high doses of resveratrol generates micromolar concentrations of parent and much higher levels of glucuronide and sulfate conjugates in the plasma, which might contribute to cancer chemopreventive activity.

TL;DR: Resveratrol merits further clinical evaluation as a potential colorectal cancer chemopreventive agent after it was found to be well tolerated and to produce levels in the human gastrointestinal tract of an order of magnitude sufficient to elicit anticarcinogenic effects.

TL;DR: The occurrence of mild to moderate side effects is likely to limit the doses employed in future trials to significantly less than this amount, and what additional information is needed is suggested to increase the chances of success in future clinical trials.

TL;DR: The published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources, and animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials.