K
Kevin J. Frankowski
Researcher at University of North Carolina at Chapel Hill
Publications - 71
Citations - 1377
Kevin J. Frankowski is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Chemistry & κ-opioid receptor. The author has an hindex of 20, co-authored 63 publications receiving 1201 citations. Previous affiliations of Kevin J. Frankowski include University of Delaware & University of Regensburg.
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Journal ArticleDOI
Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors
Lei Zhou,Kimberly M. Lovell,Kevin J. Frankowski,Stephen R. Slauson,Angela Phillips,John M. Streicher,Edward L. Stahl,Cullen L. Schmid,Peter Hodder,Franck Madoux,Michael D. Cameron,Thomas E. Prisinzano,Jeffrey Aubé,Laura M. Bohn +13 more
TL;DR: Two first-in-class small molecule agonists that bias KOR signaling toward G protein coupling and away from βarrestin2 recruitment are described, which may prove to be useful tools for refining the therapeutic potential of KOR-directed signaling in vivo.
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Structure–Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase
Tsui-Fen Chou,Tsui-Fen Chou,Kelin Li,Kevin J. Frankowski,Frank J. Schoenen,Raymond J. Deshaies +5 more
TL;DR: The results nominate ML240 as a promising starting point for the development of a novel agent for the chemotherapy of cancer, and provide a rationale for developing pathway‐specific p97 inhibitors.
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Syntheses of the Stemona Alkaloids (±)-Stenine, (±)-Neostenine, and (±)-13-Epineostenine Using a Stereodivergent Diels–Alder/Azido-Schmidt Reaction
TL;DR: A tandem Diels-Alder/azido-Schmidt reaction sequence provides rapid access to the core skeleton shared by several Stemona alkaloids including stenine, neostenine, tuberostemonines, and neotuberostemonine, enabling the preparation of both (+/-)-stenine and (+/--neostenines from the same diene/dienophile combination.
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Grubbs' catalyst in paraffin: an air-stable preparation for alkene metathesis.
TL;DR: A homogeneous mixture of Grubbs' catalyst in paraffin wax was shown to catalyze three important types of metathesis reactions: ring-closing meetingathesis, alkene dimerization, and alkene cross-metathesis.
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Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization
TL;DR: A two-stage protocol for converting lactams, many of which can be prepared through the intramolecular Schmidt reaction of keto azides, is presented and a convenient route to lactams bearing a methoxy group adjacent to nitrogen is provided.