K
Kevin K. Lin
Researcher at University of California, San Francisco
Publications - 28
Citations - 4030
Kevin K. Lin is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 13, co-authored 15 publications receiving 2773 citations.
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Journal ArticleDOI
Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial
Robert L. Coleman,Amit M. Oza,Domenica Lorusso,Carol Aghajanian,Ana Oaknin,Andrew Dean,Nicoletta Colombo,Johanne I Weberpals,Andrew R Clamp,Giovanni Scambia,Alexandra Leary,Robert W Holloway,Margarita Amenedo Gancedo,Peter C.C. Fong,Jeffrey C. Goh,David M. O'Malley,Deborah K. Armstrong,Jesus Garcia-Donas,Elizabeth M. Swisher,Anne Floquet,Gottfried E. Konecny,Iain A. McNeish,Clare L. Scott,Terri Cameron,Lara Maloney,Jeff Isaacson,Sandra Goble,Caroline Grace,Thomas Harding,Mitch Raponi,James Sun,Kevin K. Lin,Heidi Giordano,Jonathan A. Ledermann,Martin Buck,A Dean,Michael Friedlander,J C Goh,Paul R. Harnett,G Kichenadasse,C L Scott,H Denys,Luc Dirix,Ignace Vergote,Laurie Elit,Prafull Ghatage,Amit M. Oza,Marie Plante,Diane Provencher,J I Weberpals,Stephen Welch,A Floquet,Laurence Gladieff,Florence Joly,A Leary,Alain Lortholary,Jean-Pierre Lotz,J. Medioni,Olivier Tredan,Benoit You,A El-Balat,C Hänle,P Krabisch,T Neunhöffer,M Pölcher,Pauline Wimberger,Amnon Amit,S Kovel,M Leviov,Tamar Safra,Ronnie Shapira-Frommer,Salomon M. Stemmer,Alessandra Bologna,N Colombo,Domenica Lorusso,Sandro Pignata,Roberto Sabbatini,G Scambia,Stefano Tamberi,Claudio Zamagni,P C Fong,A O'Donnell,M Amenedo Gancedo,A Casado Herraez,J Garcia-Donas,E M Guerra,A Oaknin,I Palacio,Iris L. Romero,A Sanchez,Susana Banerjee,A Clamp,Y Drew,Hani Gabra,D Jackson,Jonathan A. Ledermann,I A McNeish,Christine Parkinson,Melanie E Powell,C Aghajanian,D K Armstrong,Michael J. Birrer,Mary K. Buss,Setsuko K. Chambers,L-m Chen,Robert L. Coleman,R W Holloway,G E Konecny,L Ma,Mark A. Morgan,R T Morris,David G. Mutch,D M O'Malley,B M Slomovitz,E M Swisher,T Vanderkwaak,M Vulfovich +116 more
TL;DR: This trial assessed rucaparib versus placebo after response to second-line or later platinum-based chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-wide loss of heterozygosity.
Journal ArticleDOI
Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial
Elizabeth M. Swisher,Kevin K. Lin,Amit M. Oza,Clare L. Scott,Heidi Giordano,James Sun,Gottfried E. Konecny,Robert L. Coleman,Anna V. Tinker,David M. O'Malley,Rebecca Kristeleit,Ling Ma,Katherine M. Bell-McGuinn,James D. Brenton,Janiel M. Cragun,Ana Oaknin,Isabelle Ray-Coquard,Maria I. Harrell,Elaina Mann,Scott H. Kaufmann,Anne Floquet,Alexandra Leary,Thomas Harding,Sandra Goble,Lara Maloney,Jeff Isaacson,Andrew R. Allen,Lindsey Rolfe,Roman Yelensky,Mitch Raponi,Iain A. McNeish +30 more
TL;DR: The ability of tumour genomic LOH, quantified with a next-generation sequencing assay, to predict response to rucaparib, an oral PARP inhibitor, was assessed in ARIEL2, an international, multicentre, two-part, phase 2, open-label study.
Journal ArticleDOI
Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC
Annette O Walter,Robert Tjin Tham Sjin,Henry J. Haringsma,Kadoaki Ohashi,Jing Sun,Kwangho Lee,Aleksander Dubrovskiy,Matthew T. Labenski,Zhendong Zhu,Zhigang Wang,Michael Sheets,Thia St Martin,Russell Karp,Dan van Kalken,Prasoon Chaturvedi,Deqiang Niu,M. Nacht,Russell C. Petter,William F. Westlin,Kevin K. Lin,Sarah Jaw-Tsai,Mitch Raponi,Terry Van Dyke,Jeff Etter,Zoe Weaver,William Pao,Juswinder Singh,Andrew Simmons,Thomas Harding,Andrew E. Allen +29 more
TL;DR: CO-1686 is the fi rst drug of its class in clinical development for the treatment of T790M-positive NSCLC, potentially offering potent inhibition of mutant EGFR while avoiding the on-target toxicity observed with inhibition of the WT EGFR.
Journal ArticleDOI
Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.
Olga Kondrashova,Olga Kondrashova,Minh Nguyen,Kristy Shield-Artin,Kristy Shield-Artin,Anna V. Tinker,Nelson N.H. Teng,Maria I. Harrell,Michael J. Kuiper,Gwo-Yaw Ho,Gwo-Yaw Ho,Gwo-Yaw Ho,Holly E. Barker,Holly E. Barker,Maria Jasin,Rohit Prakash,Elizabeth M. Kass,Meghan R. Sullivan,Gregory J. Brunette,Kara A. Bernstein,Robert L. Coleman,Anne Floquet,Michael Friedlander,Ganessan Kichenadasse,David M. O'Malley,Amit M. Oza,James Sun,Liliane Robillard,Lara Maloney,David D.L. Bowtell,David D.L. Bowtell,David D.L. Bowtell,Heidi Giordano,Matthew Wakefield,Matthew Wakefield,Scott H. Kaufmann,Andrew Simmons,Thomas Harding,Mitch Raponi,Iain A. McNeish,Elizabeth M. Swisher,Kevin K. Lin,Clare L. Scott,Clare L. Scott,Clare L. Scott +44 more
TL;DR: Evidence is provided for these primary mutations in RAD51C and RAD51D in conferring PARPi sensitivity and secondary mutations as a mechanism of acquired PARPi resistance underpins the need for early delivery of PARPi therapy and for combination strategies.
Journal ArticleDOI
BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma
Kevin K. Lin,Maria I. Harrell,Amit M. Oza,Ana Oaknin,Isabelle Ray-Coquard,Anna V. Tinker,Elena Helman,Marc R. Radke,Carmen Say,Lan Thanh Vo,Elaina Mann,Jeffrey D. Isaacson,Lara Maloney,David M. O'Malley,Setsuko K. Chambers,Scott H. Kaufmann,Clare L. Scott,Gottfried E. Konecny,Robert L. Coleman,James Sun,Heidi Giordano,James D. Brenton,Thomas Harding,Iain A. McNeish,Elizabeth M. Swisher +24 more
TL;DR: Targeted next-generation sequencing of circulating cell-free DNA extracted from pretreatment and postprogression plasma in patients with deleterious germline or somatic BRCA mutations treated with the PARP inhibitor rucaparib found BRCa reversion mutations detected in cfDNA from platinum-resistant or platinum-refractory HGOC.