K
Kevin Looi
Researcher at University of Western Australia
Publications - 35
Citations - 581
Kevin Looi is an academic researcher from University of Western Australia. The author has contributed to research in topics: Respiratory epithelium & Occludin. The author has an hindex of 12, co-authored 34 publications receiving 397 citations. Previous affiliations of Kevin Looi include Telethon Institute for Child Health Research & Curtin University.
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Journal ArticleDOI
Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis
Luke W. Garratt,Erika N. Sutanto,Erika N. Sutanto,Kak-Ming Ling,Kevin Looi,Thomas Iosifidis,K. Martinovich,Nicole C. Shaw,E. Kicic-Starcevich,E. Kicic-Starcevich,Darryl A. Knight,Darryl A. Knight,Sarath Ranganathan,Sarath Ranganathan,Stephen M. Stick,Anthony Kicic +15 more
TL;DR: Both MMP-9/TIMP-1 and active M MP-9 increased with free neutrophil elastase and were associated with bronchiectasis, further demonstrating that freeNeutrophilElastase activity should be considered an important precursor to cystic fibrosis structural disease.
Journal ArticleDOI
Conditionally reprogrammed primary airway epithelial cells maintain morphology, lineage and disease specific functional characteristics.
K. Martinovich,Thomas Iosifidis,Alysia G. Buckley,Kevin Looi,Kak-Ming Ling,Erika N. Sutanto,E. Kicic-Starcevich,Luke W. Garratt,Nicole C. Shaw,Samuel T. Montgomery,Francis J. Lannigan,Darryl A. Knight,Anthony Kicic,Stephen M. Stick +13 more
TL;DR: It is shown that conditionally reprogrammed airway epithelial cells (CRAECs) can be established from both healthy and diseased phenotypes, and that CRAECs derived from children maintain lineage, phenotypic and importantly disease-specific functional characteristics over a specified passage range.
Journal ArticleDOI
Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma.
Kevin Looi,Alysia G. Buckley,Paul Rigby,Luke W. Garratt,Thomas Iosifidis,Graeme R. Zosky,Alexander N. Larcombe,Alexander N. Larcombe,Francis J. Lannigan,Francis J. Lannigan,Kak-Ming Ling,K. Martinovich,E. Kicic-Starcevich,E. Kicic-Starcevich,Nicole C. Shaw,Erika N. Sutanto,Erika N. Sutanto,Darryl A. Knight,Darryl A. Knight,Anthony Kicic,Stephen M. Stick +20 more
TL;DR: No studies have yet assessed the effect of human rhinovirus infection on the expression and resultant barrier function in epithelial tight junctions in childhood asthma.
Journal ArticleDOI
Impaired airway epithelial cell responses from children with asthma to rhinoviral infection.
Anthony Kicic,Paul T. Stevens,Erika N. Sutanto,Erika N. Sutanto,E. Kicic-Starcevich,E. Kicic-Starcevich,Kak-Ming Ling,Kevin Looi,K. Martinovich,Luke W. Garratt,Thomas Iosifidis,Thomas Iosifidis,Nicole C. Shaw,Alysia G. Buckley,Paul Rigby,Francis J. Lannigan,Darryl A. Knight,Stephen M. Stick +17 more
TL;DR: The airway epithelium forms an effective immune and physical barrier that is essential for protecting the lung from potentially harmful inhaled stimuli including viruses.
Journal ArticleDOI
ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma.
Peter A. B. Wark,Peter A. B. Wark,Prabuddha S. Pathinayake,Gerard E. Kaiko,Kristy Nichol,Ayesha Ali,Ling Chen,Erika N. Sutanto,Erika N. Sutanto,Luke W. Garratt,Sukhwinder Singh Sohal,Wenying Lu,Mathew Suji Eapen,Christopher Oldmeadow,Nathan W. Bartlett,Andrew T. Reid,Punnam Chander Veerati,Alan Hsu,Kevin Looi,Kevin Looi,Thomas Iosifidis,Thomas Iosifidis,Stephen M. Stick,Stephen M. Stick,Philip M. Hansbro,Anthony Kicic +25 more
TL;DR: In this paper, the ACE2 receptor and serine proteases were found to be associated with older age and male sex, but not with pack-years smoked in patients with asthma and COPD.