Kevin R. Francis

TL;DR: An overview of the current knowledge driving the stromal vascular fraction, its regulatory issues and existing studies, and potential unmapped applications are provided.

TL;DR: The reprogramming of samples from individuals affected with rare diseases to induced pluripotent stem cells, current and future applications for this technology, and how integration of genome editing to rare disease research will help to improve the understanding of disease pathogenesis and lead to patient therapies are discussed.

TL;DR: It is concluded that statin‐mediated cholesterol depletion may coordinate vascular smooth muscle cell migration and adhesion to different extracellular matrix proteins and regulate cellular stiffness and cytoskeletal orientation, thus impacting the biomechanics of the cell.

TL;DR: In this paper, an analysis of CME dynamics in the context of human disorders of cholesterol metabolism is presented, showing that inhibition of post-squalene cholesterol biosynthesis impairs CME.

TL;DR: It is concluded that sterols lower the energetic costs of membrane bending during pit formation and vesicular scission during CME and suggest reduced CME contributes to cellular phenotypes observed within disorders of cholesterol metabolism.