K
Khursheed Iqbal
Researcher at University of Kansas
Publications - 34
Citations - 2419
Khursheed Iqbal is an academic researcher from University of Kansas. The author has contributed to research in topics: Trophoblast & Placentation. The author has an hindex of 11, co-authored 25 publications receiving 2026 citations. Previous affiliations of Khursheed Iqbal include Beckman Research Institute & Friedrich Loeffler Institute.
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Journal ArticleDOI
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
Tian-Peng Gu,Fan Guo,Hui Yang,Hai-Ping Wu,Hai-Ping Wu,Gui-Fang Xu,Wei Liu,Zhi-Guo Xie,Linyu Shi,Xinyi He,Seung-Gi Jin,Khursheed Iqbal,Yujiang Geno Shi,Zixin Deng,Piroska E. Szabó,Gerd P. Pfeifer,Jinsong Li,Guoliang Xu +17 more
TL;DR: Tet3-mediated DNA hydroxylation is involved in epigenetic reprogramming of the zygotic paternal DNA following natural fertilization and may also contribute to somatic cell nuclear reprograming during animal cloning.
Journal ArticleDOI
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine
TL;DR: It is shown that in advanced pronuclear-stage zygotes the paternal pronucleus contains substantial amounts of 5hmC but lacks 5mC, and 5mMC oxidation is part of the early life cycle of mammals.
Journal ArticleDOI
Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming
Khursheed Iqbal,Diana A. Tran,Diana A. Tran,Arthur X. Li,Charles Warden,Angela Y. Bai,Angela Y. Bai,Purnima Singh,Xiwei Wu,Gerd P. Pfeifer,Gerd P. Pfeifer,Piroska E. Szabó,Piroska E. Szabó +12 more
TL;DR: It is suggested that endocrine-disrupting chemicals exert direct epigenetic effects in exposed fetal germ cells, which are corrected by reprogramming events in the next generation.
Journal ArticleDOI
Hemochorial placentation: development, function, and adaptations.
TL;DR: An overview of the basics of hemochorial placental development and function is provided, perspectives on major discoveries that have shaped placental research are provided, and thoughts on strategies for future investigation are provided.
Journal ArticleDOI
Hypoxia and Placental Development.
TL;DR: The capacity of the placenta for adaptation to environmental challenges highlights the importance of its plasticity in safeguarding a healthy pregnancy and that of the trophoblast stem cells in mouse, rat, and human placentation.